Myosin, Smooth Muscle (SMMS-1) Mouse Monoclonal Antibody
Specialties: Breast/Gynecological Pathology
Smooth Muscle Myosin, heavy chain (SMMS-1) is a cytoplasmic structural protein that is a major component of the contractile apparatus of the smooth muscle cells. SMMS-1 is also a myoepithelium-associated protein. Anti-SMMS-1 is a mouse monoclonal antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human myoepithelial cells. It is very helpful in identifying myoepithelial cells in benign sclerosing breast lesions and demonstrating their absence in invasive breast carcinomas.1-4
- Werling, Robert W et al. "Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain." The American journal of surgical pathology vol. 27,1 (2003): 82-90.
- Agoff, S N et al. "Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma." Applied immunohistochemistry & molecular morphology : AIMM vol. 9,2 (2001): 164-9.
- Popnikolov, Nikolay K et al. "Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrix-producing and spindle cell carcinomas." American journal of clinical pathology vol. 120,2 (2003): 161-7.
- Lazard, D et al. "Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue." Proceedings of the National Academy of Sciences of the United States of America vol. 90,3 (1993): 999-1003.
Specifications
- Reactivity: paraffin
- Control: Breast (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC29821050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 298M-14 |
| 0.5 mL concentrate | 298M-15 |
| 1.0 mL concentrate | 298M-16 |
| 1.0 mL predilute ready-to-use | 298M-17 |
| 7.0 mL predilute ready-to-use | 298M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 298M-14 |
| 0.5 mL concentrate | 298M-15 |
| 1.0 mL concentrate | 298M-16 |
| 1.0 mL predilute ready-to-use | 298M-17 |
| 7.0 mL predilute ready-to-use | 298M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 298M-14 |
| 0.5 mL concentrate | 298M-15 |
| 1.0 mL concentrate | 298M-16 |
| 1.0 mL predilute ready-to-use | 298M-17 |
| 7.0 mL predilute ready-to-use | 298M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO | 298M-14-RUO |
| 0.5 mL concentrate (RUO | 298M-15-RUO |
| 1.0 mL concentrate (RUO | 298M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO | 298M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO | 298M-18-RUO |
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