Calcitonin Rabbit Polyclonal Antibody

Calcitonin
Calcitonin polyclonal antibody shows a strong cytoplasmic expression of calcitonin protein of medullary thyroid carcinoma.

Calcitonin Rabbit Polyclonal Antibody

Specialties: Cytopathology Head/Neck Pathology

Updated: 2017-05-24 08:46:09

Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that participates in calcium and phosphorus metabolism.1 Immunohistochemical staining with anti-calcitonin antibody is an effective way of demonstrating calcitonin-producing parafollicular C cells in the thyroid.2,3 Immunohistochemical studies of C-cell hyperplasia and medullary thyroid carcinomas stain will predominately stain positive for calcitonin.2 Other tissues such as the lungs and intestinal tract can also synthesize calcitonin.1 Expression of Calcitonin in both non-neoplastic and neoplastic neuroendocrine cells of these organs, such as carcinoids and small cell lung carcinomas, may be seen.4

  1. Calcitonin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscalcitonin.html. Accessed May 3, 2017.
  2. Matias-Guiu X, et al. Medullary thyroid carcinoma: a 25-year perspective. Endocr Pathol. 2014; 25:21-9.
  3. Fisher S, et al. Application of immunohistochemistry to thyroid neoplasms. Arch Pathol Lab Med. 2008;132:359-72.
  4. Tsutsumi Y. Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung. Hum Pathol. 1989; 20: 869-902.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: thyroid medullary carcinoma
  • Dilution Range: 1:200-1:1000*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate229A-14
0.5 mL concentrate229A-15
1 mL concentrate229A-16
1 mL predilute229A-17
7 mL predilute229A-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate229A-14
0.5 mL concentrate229A-15
1 mL concentrate229A-16
1 mL predilute229A-17
7 mL predilute229A-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate229A-14
0.5 mL concentrate229A-15
1 mL concentrate229A-16
1 mL predilute229A-17
7 mL predilute229A-18

For research use only (RUO) in Japan

0.1 mL concentrate229A-14-RUO
0.5 mL concentrate229A-15-RUO
1 mL concentrate229A-16-RUO
1 mL predilute229A-17-RUO
7 mL predilute229A-18-RUO

 

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