Galectin-3 (9C4) Mouse Monoclonal Antibody

Galectin-3
Galectin-3 antibody shows a strong, diffuse, and cytoplasmic staining in papillary thyroid carcinoma.

Galectin-3 (9C4) Mouse Monoclonal Antibody

Specialties: Cytopathology Head/Neck Pathology

Updated: 2017-05-24 08:46:09

Galectin-3 is a 30-kD protein, a member of the beta-galactosidase-binding lectin family. Galectin-3 is associated with cell growth, adhesion, inflammation, mRNA processing, and apoptosis.1-2 Reportedly, Galectin-3 aberrant expression is related to malignant transformation and metastasis in carcinomas of the breast, colon and thyroid.3-5 Galectin-3 reactivity can be seen in the nucleus of neutrophils, vascular endothelium, carcinomas of the colon, breast, and thyroid. Galectin-3 may be useful in the differentiation  of benign and malignant thyroid neoplasms.6-7 Galectin-3 may also be useful in the identification of certain liver disorders.8

  1. Inohara H, et al. Expression of galectin-3 in fine-needle aspirates as a diagnostic marker differentiating benign from malignant thyroid neoplasms. Cancer. 1999; 85:2475-84.
  2. Herrmann ME, et al. Immunohistochemical expression of galectin-3 in benign and malignant thyroid lesions. Arch Pathol Lab Med. 2002; 126:710-3.
  3. Papotti M, et al. Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma. Eur J Endocrinol. 2002; 147: 515-21.
  4. Bartolazzi A, et al. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions. Lancet. 2001; 357:1644-50.
  5. Orlandi F, et al. Galectin-3 is a presurgical marker of human thyroid carcinoma. Cancer Res. 1998; 58:3015-20.
  6. Gasbarri A, et al. Galectin-3 and CD44v6 isoforms in the preoperative evaluation of thyroid nodules. J Clin Oncol. 1999; 17:3494-502.
  7. Chiu CG, et al. Diagnostic utility of galectin-3 in thyroid cancer. Am J Pathol. 2010; 176:2067-81.
  8. Hsu DK, et al. Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma. Int J Cancer. 1999; 81:519-26.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: papillary thyroid carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate255M-14
0.5 mL concentrate255M-15
1 mL concentrate255M-16
1 mL predilute255M-17
7 mL predilute255M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate255M-14
0.5 mL concentrate255M-15
1 mL concentrate255M-16
1 mL predilute255M-17
7 mL predilute255M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate255M-14
0.5 mL concentrate255M-15
1 mL concentrate255M-16
1 mL predilute255M-17
7 mL predilute255M-18

For research use only (RUO) in Japan

0.1 mL concentrate255M-14-RUO
0.5 mL concentrate255M-15-RUO
1 mL concentrate255M-16-RUO
1 mL predilute255M-17-RUO
7 mL predilute255M-18-RUO

 

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