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Androgen Receptor (SP107)

Rabbit Monoclonal


Qualitative and quantitative alterations of androgen receptor expression in prostatic carcinomas and their possible implications for tumor progression and treatment are therefore of diagnostic and research interest. Findings in prostatic tumor cell lines of rat and human origin suggest that reduction of androgen receptor protein expression is accompanied by an increase in tumor aggressiveness. However, immunohistochemical analysis and binding assays have demonstrated the presence of androgen receptors in all histological types of prostatic carcinoma and in both therapy-responsive as well as therapy-unresponsive tumors.

Most of the immunohistochemical studies of androgen receptors have been related to prostatic carcinoma and experimental animals. Patients with 48% or more androgen receptor-positive cells had statistically significant better outcome in terms of both progression-free and cause-specific survival. Another study suggested that prior to therapy, androgen receptor expression alone is not related to prognosis of hormonally treated prostate cancer; however, when combined with bcl-2 expression, it acts as an independent prognostic factor for clinical progression.

The variability of androgen receptor protein content per unit nuclear area has been shown to increase with increasing histological grade, suggesting that this variability might account for the response to endocrine therapy in high grade tumors. The extent of heterogeneity of androgen receptor expression may be a useful indicator of response to hormonal therapy.1-5

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: prostate carcinoma
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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*Note: IFUs with the prefix RUO or ASR are only available for download in English.


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Last updated: 2016-01-07 14:13:45

Androgen Receptor
Androgen receptor antibody strongly labels the nuclei of prostatic adenocarcinoma.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: prostate carcinoma
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 200R-14
0.5 ml, concentrate 200R-15
1 ml, concentrate 200R-16
1 ml, predilute 200R-17
7 ml, predilute 200R-18

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 200R-14
0.5 ml, concentrate 200R-15
1 ml, concentrate 200R-16
1 ml, predilute 200R-17
7 ml, predilute 200R-18

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 200R-14
0.5 ml, concentrate 200R-15
1 ml, concentrate 200R-16
1 ml, predilute 200R-17
7 ml, predilute 200R-18

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 200R-14 (RUO)
0.5 ml, concentrate 200R-15 (RUO)
1 ml, concentrate 200R-16 (RUO)
1 ml, predilute 200R-17 (RUO)
7 ml, predilute 200R-18 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: prostate carcinoma
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

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