Androgen Receptor (SP107) Rabbit Monoclonal Antibody

Androgen Receptor
Androgen receptor antibody strongly labels the nuclei of prostatic adenocarcinoma.

Androgen Receptor (SP107) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

As a member of the steroid hormone superfamily, androgen receptor functions within distinct intracellular compartments to mediate cellular growth and transcriptional activation of androgen-regulated signaling pathways. This is accomplished through interactions between steroid ligand and androgen receptor molecules in the cytoplasm that promote dimerization and conformational change. The ligand-receptor homodimers are subsequently translocated to the nucleus for binding to genetic response elements and enhancer regions.1 Androgen receptor expression is broadly distributed across a variety of normal tissue types as well as in carcinomas of the breast2 and urothelium,3 and specifically plays a critical role in prostate development, homeostasis, and carcinogenesis.4 

  1. Roy AK, et al. Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction. Ann N Y Acad Sci. 2001; 949:44-57.
  2. Collins LC, et al. Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study. Mod Pathol. 2011; 24:924-31.
  3. Rahmani AH, et al. Implication of androgen receptor in urinary bladder cancer: a critical mini review. Int J Mol Epidemiol Genet. 2013; 4:150-55.
  4. Leach, DA, et al. Stromal Androgen Receptor in Prostate Cancer Development and Progression. Cancers (Basel). 2017; 9:pii: E10.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: prostate carcinoma
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate200R-14
0.5 mL concentrate200R-15
1 mL concentrate200R-16
1 mL predilute200R-17
7 mL predilute200R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate200R-14
0.5 mL concentrate200R-15
1 mL concentrate200R-16
1 mL predilute200R-17
7 mL predilute200R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate200R-14
0.5 mL concentrate200R-15
1 mL concentrate200R-16
1 mL predilute200R-17
7 mL predilute200R-18

For research use only (RUO) in Japan

0.1 mL concentrate200R-14-RUO
0.5 mL concentrate200R-15-RUO
1 mL concentrate200R-16-RUO
1 mL predilute200R-17-RUO
7 mL predilute200R-18-RUO

 

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