PSA (ER-PR8) Mouse Monoclonal Antibody

PSA
Benign prostate gland epithelial cells are labelled with PSA antibody.

PSA (ER-PR8) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology Genitourinary (GU) Pathology

Updated: 2017-05-24 08:46:09

Prostate-Specific Antigen (PSA) is a 33 kDa protein primarily produced by the prostatic epithelium and the epithelial lining of the periurethral glands 1. PSA is strongly expressed in both normal and neoplastic prostatic tissue. Although PSA can be considered prostate-specific, PSA and/or PSA gene expression has been detected at low levels in some extra-prostatic tissues such as normal breast tissue, breast tumors, endometrium, adrenal neoplasms and renal cell carcinomas 1, 2, 3. Anti-PSA is most useful in determining the prostatic origin of carcinomas in non-prostate tissues (metastatic disease) using IHC techniques.   This product is best used in conjunction with a panel of antibodies as, up to 27% of prostate carcinoma cases (predominantly poorly differentiated carcinomas) can be negative for this marker.4

  1. Polascik TJ, et al. J Urol. 1999; 162:293.
  2. Stenman UH, et al. Semin Cancer Biol. 1999; 9:83-93.
  3. Alanen KA, et al. Path Res Pract. 1996; 192:233-237.
  4. Varma M, et al. Histopathology. 2005; 47:1-16.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate, prostate carcinoma
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate324M-14
0.5 mL concentrate324M-15
1 mL concentrate324M-16
1 mL predilute324M-17
7 mL predilute324M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate324M-14
0.5 mL concentrate324M-15
1 mL concentrate324M-16
1 mL predilute324M-17
7 mL predilute324M-18

For research use only (RUO) in the EU

0.1 mL concentrate324M-14-RUO
0.5 mL concentrate324M-15-RUO
1 mL concentrate324M-16-RUO
1 mL predilute324M-17-RUO
7 mL predilute324M-18-RUO

For research use only (RUO) in Japan

0.1 mL concentrate324M-14-RUO
0.5 mL concentrate324M-15-RUO
1 mL concentrate324M-16-RUO
1 mL predilute324M-17-RUO
7 mL predilute324M-18-RUO

 

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