Prostate adenocarcinoma: p504s labeling of prostate carcinoma cells (cytoplasm) on left. Benign prostate on right.
P504s (13H4) Rabbit Monoclonal Antibody
Specialties: Genitourinary (GU) Pathology
Updated: 2023-01-05 15:19:14
P504s, a cytoplasmic 382-amino acid protein also called alpha-methylacyl-CoA racemase (AMACR), plays a role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives.1-2 While P504s may be expressed in various normal tissue types, it is rarely detected in benign prostate tissue.3 P504s immunohistochemistry is useful as an aid in identifying prostate carcinomas.1-5
- Jiang, Z et al. "P504S: a new molecular marker for the detection of prostate carcinoma." The American journal of surgical pathology vol. 25,11 (2001): 1397-404.
- Jiang, Zhong et al. "P504S/alpha-methylacyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy." The American journal of surgical pathology vol. 26,9 (2002): 1169-74.
- Jiang, Zhong et al. "Expression of alpha-methylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: a study of 761 cases." Human pathology vol. 34,8 (2003): 792-6.
- Evans, A J. "Alpha-methylacyl CoA racemase (P504S): overview and potential uses in diagnostic pathology as applied to prostate needle biopsies." Journal of clinical pathology vol. 56,12 (2003): 892-7.
- Zhou, Ming et al. "Alpha-Methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions." The American journal of surgical pathology vol. 26,7 (2002): 926-31.
Specifications
- Reactivity: paraffin
- Control: Prostate adenocarcinoma (Cytoplasmic)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 1.0 (CMC50431010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 504R-10 |
| 0.1 mL concentrate | 504R-14 |
| 0.5 mL concentrate | 504R-15 |
| 1.0 mL concentrate | 504R-16 |
| 1.0 mL predilute ready-to-use | 504R-17 |
| 7.0 mL predilute ready-to-use | 504R-18 |
For research use only (RUO) in Canada
| 25.0 mL predilute ready-to-use (RUO) | 504R-10-RUO |
| 0.1 mL concentrate (RUO) | 504R-14-RUO |
| 0.5 mL concentrate (RUO) | 504R-15-RUO |
| 1.0 mL concentrate (RUO) | 504R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 504R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 504R-18-RUO |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 504R-10 |
| 0.1 mL concentrate | 504R-14 |
| 0.5 mL concentrate | 504R-15 |
| 1.0 mL concentrate | 504R-16 |
| 1.0 mL predilute ready-to-use | 504R-17 |
| 7.0 mL predilute ready-to-use | 504R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 504R-10-RUO |
| 0.1 mL concentrate (RUO) | 504R-14-RUO |
| 0.5 mL concentrate (RUO) | 504R-15-RUO |
| 1.0 mL concentrate (RUO) | 504R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 504R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 504R-18-RUO |
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