Cytokeratin (34betaE12) Mouse Monoclonal Antibody

Cytokeratin
Cytokeratin (34betaE12) on prostate gland.

Cytokeratin (34betaE12) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Anti-Cytokeratin, 34betaE12 is an antibody to high molecular weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins 1,5,10, and 14 that are found in complex epithelia. Anti-Cytokeratin, 34betaE12 shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there has been no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, and neural tumors are unreactive with this antibody with some exceptions. Anti-Cytokeratin, 34betaE12 does label myoepithelial cells and has been shown to be useful in distinguishing prostatic adenocarcinoma from hyperplasia of the prostate. This antibody has also been useful in separating benign from malignant intraductal breast proliferations.1-6

  1. Gown AM, et al. Am J Pathol. 1984; 114:309.
  2. O’Malley FP, et al. Virch Arch A. 1990; 417:191-6.
  3. Amin MB. Arch Pathol Lab Med. 1994; 118:260-264.
  4. Wojno KJ, et al. Am J Surg Pathol. 1995; 19:251-60.
  5. Moinfar F, et al. Am J Surg Pathol. 1999; 23:1048-58.
  6. Yang XJ, et al. Am J Surg Pathol. 1999; 23:147-52.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute334M-80
0.1 mL concentrate334M-84
0.5 mL concentrate334M-85
1 mL concentrate334M-86
1 mL predilute334M-87
7 mL predilute334M-88

For in vitro diagnostic (IVD) use in Canada

25 mL predilute334M-80
0.1 mL concentrate334M-84
0.5 mL concentrate334M-85
1 mL concentrate334M-86
1 mL predilute334M-87
7 mL predilute334M-88

For in vitro diagnostic (IVD) use in Europe

25 mL predilute334M-80
0.1 mL concentrate334M-84
0.5 mL concentrate334M-85
1 mL concentrate334M-86
1 mL predilute334M-87
7 mL predilute334M-88

For research use only (RUO) in Japan

25 mL predilute334M-80-RUO
0.1 mL concentrate334M-84-RUO
0.5 mL concentrate334M-85-RUO
1 mL concentrate334M-86-RUO
1 mL predilute334M-87-RUO
7 mL predilute334M-88-RUO

 

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