Cell Marque Portfolio

Cytokeratin (34betaE12)

Mouse Monoclonal


Anti-Cytokeratin, 34betaE12 is an antibody to high molecular weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins 1,5,10, and 14 that are found in complex epithelia. Anti-Cytokeratin, 34betaE12 shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there has been no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, and neural tumors are unreactive with this antibody with some exceptions. Anti-Cytokeratin, 34betaE12 does label myoepithelial cells and has been shown to be useful in distinguishing prostatic adenocarcinoma from hyperplasia of the prostate. This antibody has also been useful in separating benign from malignant intraductal breast proliferations.1-6

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Gown AM, et al. Am J Pathol. 1984; 114:309.
  2. O’Malley FP, et al. Virch Arch A. 1990; 417:191-6.
  3. Amin MB. Arch Pathol Lab Med. 1994; 118:260-264.
  4. Wojno KJ, et al. Am J Surg Pathol. 1995; 19:251-60.
  5. Moinfar F, et al. Am J Surg Pathol. 1999; 23:1048-58.
  6. Yang XJ, et al. Am J Surg Pathol. 1999; 23:147-52.

Last updated: 2017-05-24 08:46:09

Cytokeratin
Cytokeratin (34betaE12) on prostate gland.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Gown AM, et al. Am J Pathol. 1984; 114:309.
  2. O’Malley FP, et al. Virch Arch A. 1990; 417:191-6.
  3. Amin MB. Arch Pathol Lab Med. 1994; 118:260-264.
  4. Wojno KJ, et al. Am J Surg Pathol. 1995; 19:251-60.
  5. Moinfar F, et al. Am J Surg Pathol. 1999; 23:1048-58.
  6. Yang XJ, et al. Am J Surg Pathol. 1999; 23:147-52.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate 334M-84
0.5 mL concentrate 334M-85
1 mL concentrate 334M-86
1 mL predilute 334M-87
7 mL predilute 334M-88
25 mL predilute 334M-80

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate 334M-84
0.5 mL concentrate 334M-85
1 mL concentrate 334M-86
1 mL predilute 334M-87
7 mL predilute 334M-88
25 mL predilute 334M-80

For in vitro diagnostic (IVD) use in the EU

0.1 mL concentrate 334M-84
0.5 mL concentrate 334M-85
1 mL concentrate 334M-86
1 mL predilute 334M-87
7 mL predilute 334M-88
25 mL predilute 334M-80

For research use only (RUO) in Japan

0.1 mL concentrate 334M-84-RUO
0.5 mL concentrate 334M-85-RUO
1 mL concentrate 334M-86-RUO
1 mL predilute 334M-87-RUO
7 mL predilute 334M-88-RUO
25 mL predilute 334M-80-RUO

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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References


  1. Gown AM, et al. Am J Pathol. 1984; 114:309.
  2. O’Malley FP, et al. Virch Arch A. 1990; 417:191-6.
  3. Amin MB. Arch Pathol Lab Med. 1994; 118:260-264.
  4. Wojno KJ, et al. Am J Surg Pathol. 1995; 19:251-60.
  5. Moinfar F, et al. Am J Surg Pathol. 1999; 23:1048-58.
  6. Yang XJ, et al. Am J Surg Pathol. 1999; 23:147-52.
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