Glypican-3 (1G12) Mouse Monoclonal Antibody

Glypican-3
Glypican-3 antibody displays a diffuse and cytoplasmic staining pattern in the neoplastic cells of hepatocellular carcinoma. Note non-neoplastic hepatocytes are negative for glypican-3.

Glypican-3 (1G12) Mouse Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cell growth and differentiation.1 GPC3 expression has been observed in the majority of hepatocellular carcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful marker for HCC.1-3 Additionally, this marker is expressed in many yolk sac tumors.1,4

  1. Kandil DH, et al. Glypican-3 a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 2009; 16:125-9.
  2. Coston WMP, et al. Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry. Am J Surg Pathol. 2008; 32:433-44.
  3. Capurro M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97.
  4. Zynger DL, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006; 30:1570-5.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: hepatocellular carcinoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute261M-90
0.1 mL concentrate261M-94
0.5 mL concentrate261M-95
1 mL concentrate261M-96
1 mL predilute261M-97
7 mL predilute261M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute261M-90
0.1 mL concentrate261M-94
0.5 mL concentrate261M-95
1 mL concentrate261M-96
1 mL predilute261M-97
7 mL predilute261M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute261M-90
0.1 mL concentrate261M-94
0.5 mL concentrate261M-95
1 mL concentrate261M-96
1 mL predilute261M-97
7 mL predilute261M-98

For research use only (RUO) in Japan

25 mL predilute261M-90-RUO
0.1 mL concentrate261M-94-RUO
0.5 mL concentrate261M-95-RUO
1 mL concentrate261M-96-RUO
1 mL predilute261M-97-RUO
7 mL predilute261M-98-RUO

 

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