Ep-CAM/Epithelial Specific Antigen (MOC-31) Mouse Monoclonal Antibody

Ep-CAM/Epithelial Specific Antigen
Ep-CAM/Epithelial Specific Antigen (MOC-31) on colon.

Ep-CAM/Epithelial Specific Antigen (MOC-31) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology Cytopathology

Updated: 2017-05-24 08:46:09

Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on the membrane of cells in most epithelial tissues.1  Immunoreactivity with the antibody to Ep-CAM has been seen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show Ep-CAM expression.2  Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes.1,2  In conjunction with other markers, Ep-CAM can be used as an aid in determining neoplasms of epithelial origin, such as distinguishing between lung adenocarcinoma and mesothelioma.2-4

  1. Schnell U, et al. EpCAM: structure and function in health and disease. Biochim Biophys Acta. 2013; 1828:1989-2001.
  2. Latza U, et al. Ber-Ep4: New monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol. 1990; 43:213-19.
  3. Ordóñez NG. Value of the Ber-Ep4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma: the M.D. Anderson experience and a critical review of the literature. Am J Clin Pathol. 1998; 109:85-9.
  4. Ordóñez NG. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003; 27:1031-51.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: colon adenocarcinoma
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate248M-14
0.5 mL concentrate248M-15
1 mL concentrate248M-16
1 mL predilute248M-17
7 mL predilute248M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate248M-14
0.5 mL concentrate248M-15
1 mL concentrate248M-16
1 mL predilute248M-17
7 mL predilute248M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate248M-14
0.5 mL concentrate248M-15
1 mL concentrate248M-16
1 mL predilute248M-17
7 mL predilute248M-18

For research use only (RUO) in Japan

0.1 mL concentrate248M-14-RUO
0.5 mL concentrate248M-15-RUO
1 mL concentrate248M-16-RUO
1 mL predilute248M-17-RUO
7 mL predilute248M-18-RUO

 

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