PAX-5 (24) Mouse Monoclonal Antibody

PAX-5
Nuclear labelling of germinal center and mantle zone cells by PAX-5 antibody on adenoidal tissue.

PAX-5 (24) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

PAX-5 encodes for B-cell-specific activator protein (BSAP), a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin lymphoma, Reed-Sternberg cells express PAX-5.4 PAX-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such differentiation.1,3 Diffuse large B-cell lymphomas do express PAX-5, save for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5. There is a strong association with CD20 expression.1-4

  1. Torlakovic E, et al. Am J Surg Pathol. 2002; 26:1343-50.
  2. Willenbrock K, et al. Lab Invest. 2002; 82:1103-9.
  3. Falini B, et al. Blood. 2002; 99:409-26.
  4. Schwering I, et al. Blood. 2003; 101:1505-12.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate312M-14
0.5 mL concentrate312M-15
1 mL concentrate312M-16
1 mL predilute312M-17
7 mL predilute312M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate312M-14
0.5 mL concentrate312M-15
1 mL concentrate312M-16
1 mL predilute312M-17
7 mL predilute312M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate312M-14
0.5 mL concentrate312M-15
1 mL concentrate312M-16
1 mL predilute312M-17
7 mL predilute312M-18

For research use only (RUO) in Japan

0.1 mL concentrate312M-14-RUO
0.5 mL concentrate312M-15-RUO
1 mL concentrate312M-16-RUO
1 mL predilute312M-17-RUO
7 mL predilute312M-18-RUO

 

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