DOG1 (SP31) Rabbit Monoclonal Antibody

DOG1
DOG1 antibody shows diffuse and strong staining for GI stromal tumor in a membranous/cytoplasmic reaction.

DOG1 (SP31) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

DOG1 is a calcium-dependent chloride channel protein that is encoded by a gene called TMEM16A (TMEM16 FLJ10261, ANO1, ORAOV2, and AOS2) located on chromosome 11q13.1 DOG1 has many significant functions such as regulation of the cholinergic activity of gastrointestinal smooth muscle 2, 3 and regulation of both the survival and proliferation of cells.4 Anti-DOG1 antibody has been shown to be useful in the identification of gastrointestinal stromal tumors (GIST).5

  1. Kang HG, et al. DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors. Mod Pathol. 2011; 24:866-77.
  2. Rizzo FM, et al.Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations. BMC Cancer. 2016; 16:87
  3. Katoh M, et al. FLJ10261 gene, located within the CCND1- EMS1 locus on human chromosome 1q13, encodes the eighttransmembrane protein homologous to C12orf3, C11orf25 and LJ34272 gene products. Int J Oncol. 2003; 22:1375-81.
  4. Stanich JE, et al. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011; 1044-51.
  5. Guler B, et al. Histopathological features of gastrointestinal stromal tumors and the contribution of DOG1 expression to the diagnosis. Balkan Med J. 2015; 32:388-96.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: GIST
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate244R-14
0.5 mL concentrate244R-15
1 mL concentrate244R-16
1 mL predilute244R-17
7 mL predilute244R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate244R-14
0.5 mL concentrate244R-15
1 mL concentrate244R-16
1 mL predilute244R-17
7 mL predilute244R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate244R-14
0.5 mL concentrate244R-15
1 mL concentrate244R-16
1 mL predilute244R-17
7 mL predilute244R-18

For research use only (RUO) in Japan

0.1 mL concentrate244R-14-RUO
0.5 mL concentrate244R-15-RUO
1 mL concentrate244R-16-RUO
1 mL predilute244R-17-RUO
7 mL predilute244R-18-RUO

 

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