Beta-Catenin antibody reveals a strong nuclear staining reaction in fibromatosis neoplastic cells.
Beta-Catenin (14) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Updated: 2017-05-24 08:46:09
Beta-catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. Mutations in the beta-catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis (desmoid tumors) of the breast and abdomen and, therefore, is useful in differentiating from other spindle cell neoplasms that may occur in these locations.1-4
- Alman BA, et al. Am J Pathol. 1997; 151:329-34.
- Li C, et al. Am J Pathol. 1998; 153:709-14.
- Abraham SC, et al. Hum Pathol. 2002; 33:39-46.
- Montgomery E, et al. Am J Surg Pathol. 2002; 26:1296-301.
Specifications
- Reactivity: paraffin
- Visualization: membranous, nuclear
- Control: fibromatosis of breast
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC22421040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 224M-14 |
| 0.5 mL concentrate | 224M-15 |
| 1 mL concentrate | 224M-16 |
| 1 mL predilute | 224M-17 |
| 7 mL predilute | 224M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 224M-14 |
| 0.5 mL concentrate | 224M-15 |
| 1 mL concentrate | 224M-16 |
| 1 mL predilute | 224M-17 |
| 7 mL predilute | 224M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 224M-14 |
| 0.5 mL concentrate | 224M-15 |
| 1 mL concentrate | 224M-16 |
| 1 mL predilute | 224M-17 |
| 7 mL predilute | 224M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 224M-14-RUO |
| 0.5 mL concentrate | 224M-15-RUO |
| 1 mL concentrate | 224M-16-RUO |
| 1 mL predilute | 224M-17-RUO |
| 7 mL predilute | 224M-18-RUO |
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