SATB2 (EP281) Rabbit Monoclonal Primary Antibody
Detection of SATB2 by immunohistochemistry (IHC) with SATB2 (EP281) Rabbit Monoclonal Primary Antibody may be used to aid in the diagnosis of colorectal carcinomas.
SATB2 (Special AT-rich sequence-binding protein 2) is a DNA-binding protein that is involved in transcriptional regulation and chromatin remodeling. The SATB2 protein is expressed in the epithelial cells of the colon, appendix, and rectum, the cerebral cortex, as well as developing bone. It plays a role in brain and bone development and in the regulation of stem cells in the lower gastrointestinal tract.1 �Immunohistochemistry for SATB2 is positive in colorectal carcinomas.1-3 �Immunohistochemistry for SATB2 shows a nuclear pattern of staining.
- Magnusson, Kristina et al. “SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas.â€Â The American journal of surgical pathology vol. 35,7 (2011): 937-48.
- Dragomir, Anca et al. “The role of SATB2 as a diagnostic marker for tumors of colorectal origin: Results of a pathology-based clinical prospective study.â€Â American journal of clinical pathology vol. 141,5 (2014): 630-8.
- Berg, Kyra B, and David F Schaeffer. “SATB2 as an Immunohistochemical Marker for Colorectal Adenocarcinoma: A Concise Review of Benefits and Pitfalls.â€Â Archives of pathology & laboratory medicine vol. 141,10 (2017): 1428-1433.
Specifications
- Dilution Range: 1:25-1:100 *
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