Cytokeratin, LMW (AE1) Mouse Monoclonal Antibody

Cytokeratin, LMW
Cytokeratin, LMW (AE1) on prostate.

Cytokeratin, LMW (AE1) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Anti-cytokeratin, low molecular weight (AE1) antibody labels acidic keratins K10, K14, K15, K16, and K19. Anti-cytokeratin (AE1) reactivity is seen in most normal and neoplastic cells of epithelial origin.  Anti-cytokeratin (AE1) is a useful immunohistochemical reagent for distinguishing between poorly differentiated carcinomas and non-epithelial neoplasms.1-5

  1. Tyler, CR. Immunoperoxidase techniques: practical and theoretical aspects. Arch Pathol Lab Med. 1978; 102:113-21.
  2. Weiss RA, et al. Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 1984; 98:1397-406.
  3. Swanson PE, et al. Heffalumps, jagulars, and cheshire cats. A commentary on cytokeratins and soft tissue sarcomas. Am J Clin Pathol 1991; 95:S2-7.
  4. Eusebi V, et al. Keratin-positive epithelioid angiosarcoma of thyroid. A report of four cases. Am J Clin Pathol. 1990; 14:737-47.
  5. Dabbs DJ. Diagnostic Immunohistochemistry. Churchhill Living­stone. 2002; 166-74.
  6. Lopez-Beltran A, et al. Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. Virchows Arch. 2001; 438:552-7.
  7. Kitazawa R, et al. In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma. Virchows Arch. 1999; 435:137-42.
  8. Judkins AR, et al. Sensitivity and specificity of antibodies on necrotic tumor tissue. Am J Clin Pathol. 1998; 110:641-6.
  9. Demetris AJ, et al. Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. Am J Pathol. 1996; 149:439-48.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate, salivary gland
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate301M-14
0.5 mL concentrate301M-15
1 mL concentrate301M-16
1 mL predilute301M-17
7 mL predilute301M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate301M-14
0.5 mL concentrate301M-15
1 mL concentrate301M-16
1 mL predilute301M-17
7 mL predilute301M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate301M-14
0.5 mL concentrate301M-15
1 mL concentrate301M-16
1 mL predilute301M-17
7 mL predilute301M-18

For research use only (RUO) in Japan

0.1 mL concentrate301M-14-RUO
0.5 mL concentrate301M-15-RUO
1 mL concentrate301M-16-RUO
1 mL predilute301M-17-RUO
7 mL predilute301M-18-RUO

 

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