Cell Marque Portfolio

CD20 (L26)

Mouse Monoclonal


CD20 is a transmembrane protein in late B-cell precursors and mature B-cells that plays a role in regulating proliferation and differentiation. CD20 expression is lost at the plasma cell stage of differentiation.1 Anti-CD20 (pan B-cell)2 has rarely been detected in T-cell malignancies, and is a dependable marker of B-cell lymphomas3 such as DLBCL.4 CD20 expression is present in some thymomas.

Specialties: Hematopathology

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil, lymph node
  • Isotype: IgG2a/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Tedder T, et al. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994; 15:450-4.
  2. Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22.
  3. Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12.
  4. Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.

Last updated: 2017-05-24 08:46:09

CD20
CD20 (L26) on tonsil.

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Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil, lymph node
  • Isotype: IgG2a/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Tedder T, et al. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994; 15:450-4.
  2. Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22.
  3. Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12.
  4. Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate 120M-84
0.5 mL concentrate 120M-85
1 mL concentrate 120M-86
1 mL predilute 120M-87
7 mL predilute 120M-88
25 mL predilute 120M-80

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate 120M-84
0.5 mL concentrate 120M-85
1 mL concentrate 120M-86
1 mL predilute 120M-87
7 mL predilute 120M-88
25 mL predilute 120M-80

For in vitro diagnostic (IVD) use in the EU

0.1 mL concentrate 120M-84
0.5 mL concentrate 120M-85
1 mL concentrate 120M-86
1 mL predilute 120M-87
7 mL predilute 120M-88
25 mL predilute 120M-80

For research use only (RUO) in Japan

0.1 mL concentrate 120M-84-RUO
0.5 mL concentrate 120M-85-RUO
1 mL concentrate 120M-86-RUO
1 mL predilute 120M-87-RUO
7 mL predilute 120M-88-RUO

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil, lymph node
  • Isotype: IgG2a/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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References


  1. Tedder T, et al. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994; 15:450-4.
  2. Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22.
  3. Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12.
  4. Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.
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