Cell Marque Portfolio

SATB2 (EP281)

Rabbit Monoclonal


Special AT-rich sequence-binding protein 2 (SATB2) is a recently described marker that functions as a nuclear matrix-associated transcription factor. It has been reported that SATB2, in combination with CK20, could identify almost all colorectal carcinomas,1 including poorly differentiated colorectal carcinomas2. Upper gastrointestinal (GI) carcinomas and pancreatic ductal carcinomas are usually negative for SATB2,1 and ovarian carcinomas, lung adenocarcinomas, and adenocarcinomas from other origin are rarely positive for SATB2.1,2 Therefore, SATB2 is a good marker for identifying a carcinoma of colorectal origin when working on a tumor of unknown primary.1,2,5 Another potential utility of SATB2 is to identify neuroendocrine neoplasms/carcinomas of the left colon and rectum because SATB2 is usually negative in other neuroendocrine neoplasms of the GI tract, pancreas, and lung.3 More recently, it has been shown in literature that SATB2 is a sensitive marker for tumors with osteoblastic differentiation.4

Specialties: Gastrointestinal (GI) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon adenocarcinoma, colon
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?



*Note: IFUs with the prefix RUO or ASR are only available for download in English.


Click here to learn about keycodes

References


  1. Mangnusso K, et al. Am J Surg Pathol. 2011; 35:937-948.
  2. Lin F, et al. Arch Pathol Lab Mad. 2014; 138:1015-26.
  3. Li Z, et al. Mod Pathol. 2013; 26:164A.
  4. Conner JR, et al. Histopathology. 2013; 63:182-193.
  5. Dragomir A, et al. Am J Clin Pathol 2014; 141:630-38.

Last updated: 2016-09-29 13:18:40

SATB2
Nuclear expression by anti-SATB2 is highlighted on colorectal carcinoma.

Mouse over to zoom, use scroll wheel to zoom in/out

Tap image once to activate zoom lens


Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon adenocarcinoma, colon
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Mangnusso K, et al. Am J Surg Pathol. 2011; 35:937-948.
  2. Lin F, et al. Arch Pathol Lab Mad. 2014; 138:1015-26.
  3. Li Z, et al. Mod Pathol. 2013; 26:164A.
  4. Conner JR, et al. Histopathology. 2013; 63:182-193.
  5. Dragomir A, et al. Am J Clin Pathol 2014; 141:630-38.

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 384R-14
0.5 ml, concentrate 384R-15
1 ml, concentrate 384R-16
1 ml, predilute 384R-17
7 ml, predilute 384R-18
25 ml, predilute 384R-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 384R-14
0.5 ml, concentrate 384R-15
1 ml, concentrate 384R-16
1 ml, predilute 384R-17
7 ml, predilute 384R-18
25 ml, predilute 384R-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 384R-14
0.5 ml, concentrate 384R-15
1 ml, concentrate 384R-16
1 ml, predilute 384R-17
7 ml, predilute 384R-18
25 ml, predilute 384R-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 384R-14 (RUO)
0.5 ml, concentrate 384R-15 (RUO)
1 ml, concentrate 384R-16 (RUO)
1 ml, predilute 384R-17 (RUO)
7 ml, predilute 384R-18 (RUO)
25 ml, predilute 384R-10 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon adenocarcinoma, colon
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

References


  1. Mangnusso K, et al. Am J Surg Pathol. 2011; 35:937-948.
  2. Lin F, et al. Arch Pathol Lab Mad. 2014; 138:1015-26.
  3. Li Z, et al. Mod Pathol. 2013; 26:164A.
  4. Conner JR, et al. Histopathology. 2013; 63:182-193.
  5. Dragomir A, et al. Am J Clin Pathol 2014; 141:630-38.
Request More Information