Cell Marque Portfolio

SOX-10 (EP268)

Rabbit Monoclonal


Sry-related HMG-BOX gene 10 (SOX-10) is a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage.1 It has been recently shown to be a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes.2 SOX-10 was expressed by metastatic melanomas in sentinel lymph nodes, but not by other lymph node components such as dendritic cells which usually express S100 protein. Anti-SOX-10 has been shown to be superior to all other immunostains in detecting residual invasive and in situ melanoma.1-5  Anti-SOX-10 is also a useful marker in detecting both the in situ and invasive components of desmoplastic melanoma.6 It is known that the commonly used melanoma markers, anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas5 while it has been reported that anti-SOX-10 was moderately to strongly expressed in almost all desmoplastic melanomas.2 SOX-10 is diffusely expressed in schwannomas and neurofibromas. SOX-10 presence was not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas.2

Specialties: Dermatopathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, skin melanocytes
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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Last updated: 2016-11-22 12:14:40

SOX-10
Malignant melanoma demonstrates nuclear staining by SOX-10 antibody.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, skin melanocytes
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 383R-14
0.5 ml, concentrate 383R-15
1 ml, concentrate 383R-16
1 ml, predilute 383R-17
7 ml, predilute 383R-18
25 ml, predilute 383R-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 383R-14
0.5 ml, concentrate 383R-15
1 ml, concentrate 383R-16
1 ml, predilute 383R-17
7 ml, predilute 383R-18
25 ml, predilute 383R-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 383R-14
0.5 ml, concentrate 383R-15
1 ml, concentrate 383R-16
1 ml, predilute 383R-17
7 ml, predilute 383R-18
25 ml, predilute 383R-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 383R-14 (RUO)
0.5 ml, concentrate 383R-15 (RUO)
1 ml, concentrate 383R-16 (RUO)
1 ml, predilute 383R-17 (RUO)
7 ml, predilute 383R-18 (RUO)
25 ml, predilute 383R-10 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, skin melanocytes
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

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