SOX-10 (EP268) Rabbit Monoclonal Antibody

SOX-10
Malignant melanoma demonstrates nuclear staining by SOX-10 antibody.

SOX-10 (EP268) Rabbit Monoclonal Antibody

Specialties: Dermatopathology

Updated: 2017-05-24 08:46:09

Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development, and acts as a nucleocytoplasmic shuttle protein.1  SOX-10 is expressed in melanocytic lineages, and is a sensitive marker of melanoma for conventional, and desmoplastic subtypes.2-3 In normal tissues, SOX-10 is expressed in melanocytes, and myoepithelial cells.4

  1. Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
  2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
  3. Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
  4. Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, skin melanocytes
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute383R-10
0.1 mL concentrate383R-14
0.5 mL concentrate383R-15
1 mL concentrate383R-16
1 mL predilute383R-17
7 mL predilute383R-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute383R-10
0.1 mL concentrate383R-14
0.5 mL concentrate383R-15
1 mL concentrate383R-16
1 mL predilute383R-17
7 mL predilute383R-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute383R-10
0.1 mL concentrate383R-14
0.5 mL concentrate383R-15
1 mL concentrate383R-16
1 mL predilute383R-17
7 mL predilute383R-18

For research use only (RUO) in Japan

25 mL predilute383R-10-RUO
0.1 mL concentrate383R-14-RUO
0.5 mL concentrate383R-15-RUO
1 mL concentrate383R-16-RUO
1 mL predilute383R-17-RUO
7 mL predilute383R-18-RUO

 

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