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SOX-10 (EP268)

Rabbit Monoclonal


Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development, and acts as a nucleocytoplasmic shuttle protein.1  SOX-10 is expressed in melanocytic lineages, and is a sensitive marker of melanoma for conventional, and desmoplastic subtypes.2-3 In normal tissues, SOX-10 is expressed in melanocytes, and myoepithelial cells.4

Specialties: Dermatopathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, skin melanocytes
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Package Inserts


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SDS

References


  1. Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
  2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
  3. Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
  4. Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.

Last updated: 2017-05-24 08:46:09

SOX-10
Malignant melanoma demonstrates nuclear staining by SOX-10 antibody.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, skin melanocytes
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
  2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
  3. Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
  4. Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate 383R-14
0.5 mL concentrate 383R-15
1 mL concentrate 383R-16
1 mL predilute 383R-17
7 mL predilute 383R-18
25 mL predilute 383R-10

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate 383R-14
0.5 mL concentrate 383R-15
1 mL concentrate 383R-16
1 mL predilute 383R-17
7 mL predilute 383R-18
25 mL predilute 383R-10

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate 383R-14
0.5 mL concentrate 383R-15
1 mL concentrate 383R-16
1 mL predilute 383R-17
7 mL predilute 383R-18
25 mL predilute 383R-10

For research use only (RUO) in Japan

0.1 mL concentrate 383R-14-RUO
0.5 mL concentrate 383R-15-RUO
1 mL concentrate 383R-16-RUO
1 mL predilute 383R-17-RUO
7 mL predilute 383R-18-RUO
25 mL predilute 383R-10-RUO

 

To request information on this product in additional countries, please click the button below.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, skin melanocytes
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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References


  1. Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
  2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
  3. Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
  4. Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.
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