MyoD1 (EP212) Rabbit Monoclonal Antibody

MyoD1
Rhabdomyosarcoma cells are labeled in a nuclear pattern by anti-MyoD1.

MyoD1 (EP212) Rabbit Monoclonal Antibody

Specialties: Pediatric Pathology Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

Rhabdomyosarcomas (RMS) are the most frequent malignant soft tissue neoplasms of childhood.1 While better differentiated RMS have cross-striations or rhabdomyoblasts that allow for a confident morphologic diagnosis, less differentiated RMS resemble other small blue round-cell tumors.1 MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the myogenic differentiation pathway from the determination of mesodermal precursors into myoblasts, the differentiation of myoblasts into myotubes, and finally the maturation of myotubes into skeletal myofibers.2 Normal mature skeletal muscle does not express MyoD1 protein.1-2 MyoD1 is expressed in myoblasts before differentiation while myogenin has post-differentiation functions.2 Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase, thus, it is a better biomarker for less differentiated RMS.2 Studies suggest, anti-MyoD1 may be used together with anti-myogenin and anti-desmin as a panel of markers since any RMS is virtually never negative for all three markers simultaneously.1-2

  1. Morotti RA, et al. Am J Surg Pathol. 2006; 30:962-968..
  2. Sebire NJ, et al. J Clin Pathol. 2003; 56:412-416.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: rhabdomyosarcoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate386R-14
0.5 mL concentrate386R-15
1 mL concentrate386R-16
1 mL predilute386R-17
7 mL predilute386R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate386R-14
0.5 mL concentrate386R-15
1 mL concentrate386R-16
1 mL predilute386R-17
7 mL predilute386R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate386R-14
0.5 mL concentrate386R-15
1 mL concentrate386R-16
1 mL predilute386R-17
7 mL predilute386R-18

For research use only (RUO) in Japan

0.1 mL concentrate386R-14-RUO
0.5 mL concentrate386R-15-RUO
1 mL concentrate386R-16-RUO
1 mL predilute386R-17-RUO
7 mL predilute386R-18-RUO

 

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