Myogenin (F5D) Mouse Monoclonal Antibody

Myogenin
Nuclear labelling of rhabdomyosarcoma cells by myogenin antibody.

Myogenin (F5D) Mouse Monoclonal Antibody

Specialties: Pediatric Pathology Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

Myogenin also identified as myogenic factor 4 is a muscle specific transcription factor associated with muscle differentiation and cell cycle.1 Anti-myogenin reactivity is seen in the nuclei of myoblasts in developing muscle tissue. Anti-myogenin is a useful immunohistochemical reagent for identification of rhabdomyosarcoma.2-5

  1. Miller JB. Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin. J Cell Biol. 1990; 111:1149-59.
  2. Wang NP, et al. Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood. Am J Pathol. 1995; 147:1799-810.
  3. Cui S, et al. Evaluation of new monoclonal anti-MyoD1 and anti-myogenin antibodies for the diagnosis of rhabdomyosarcoma. Pathol Int. 1999; 49:62-8.
  4. Kaspar et al. The expression of c-Myb correlates with the levels of rhabdomyosarcoma-specific marker Myogenin. Sci Rep. 2015; 5:15090.
  5. Rudzinski et al. Myogenin, AP 2 Beta, NOS-1 and HMGA2 are surrogate markers of fusion status in rhabdomyosarcoma. Am J Surg Pathol. 2014; 38:654-9.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: rhabdomyosarcoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate296M-14
0.5 mL concentrate296M-15
1 mL concentrate296M-16
1 mL predilute296M-17
7 mL predilute296M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate296M-14
0.5 mL concentrate296M-15
1 mL concentrate296M-16
1 mL predilute296M-17
7 mL predilute296M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate296M-14
0.5 mL concentrate296M-15
1 mL concentrate296M-16
1 mL predilute296M-17
7 mL predilute296M-18

For research use only (RUO) in Japan

0.1 mL concentrate296M-14-RUO
0.5 mL concentrate296M-15-RUO
1 mL concentrate296M-16-RUO
1 mL predilute296M-17-RUO
7 mL predilute296M-18-RUO

 

To request information on this product in additional countries, please click the button below.

Literature

Request More Information