LMO2 (SP51) Rabbit Monoclonal Antibody

LMO2
LMO2 monoclonal antibody demonstrates nuclear positivity in follicular lymphoma cells.

LMO2 (SP51) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

The LIM-domain-only (LMO) family of proteins function as linkers in the co-regulation of nuclear transcription by mediating protein-protein interactions. The four members of the LMO family collectively have significant roles in cell fate determination, cell growth and differentiation, and organ development.1  LMO2 has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymphangiogenesis.2  Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma.The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin.

  1. Sang M, et al. LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins. Mol Biol Rep. 2014; 41:1067-73.
  2. Coma S, et al. GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis. 2013; 16:939-52.
  3. Natkunam Y, et al. The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas. Blood. 2007; 109:1636-42.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil, follicular lymphoma, diffuse large B-cell lymphoma
  • Dilution Range: 1:500-1:2000*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate370R-14
0.5 mL concentrate370R-15
1 mL concentrate370R-16
1 mL predilute370R-17
7 mL predilute370R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate370R-14
0.5 mL concentrate370R-15
1 mL concentrate370R-16
1 mL predilute370R-17
7 mL predilute370R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate370R-14
0.5 mL concentrate370R-15
1 mL concentrate370R-16
1 mL predilute370R-17
7 mL predilute370R-18

For research use only (RUO) in Japan

0.1 mL concentrate370R-14-RUO
0.5 mL concentrate370R-15-RUO
1 mL concentrate370R-16-RUO
1 mL predilute370R-17-RUO
7 mL predilute370R-18-RUO

 

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