HGAL (MRQ-49) Mouse Monoclonal Antibody
Specialties: Hematopathology
Human germinal center associated lymphoma (HGAL) protein is specifically expressed in the cytoplasm of germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the interfollicular and paracortical regions in normal tonsils and lymph nodes.1 Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. Anti-HGAL has the highest overall sensitivity of detecting follicular lymphoma (FL) and in detecting the interfollicular and diffuse components of FL compared with antibodies against bcl2, LMO2, CD10, and bcl6. The addition of anti-HGAL to the immunohistologic panel is beneficial in the work-up of nodal and extranodal B-cell lymphomas, and the efficacy of anti-HGAL in detecting the follicular, interfollicular, and diffuse components of FL is of particular value in the setting of variant immunoarchitectural patterns.2,3,4
- Natkunam Y, et al. Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation. Blood. 2005; 105:3979–86.
- Natkunam Y, et al. Expression of the human germinal center-associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival. Blood. 2007; 109:298-305.
- Younes SF, et al. Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components. Am J Surg Pathol. 2010; 34:1266-76.
- Higgins RA, et al. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch Pathol Lab Med. 2008; 132:441-6.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Cytoplasmic); Lymph node (Cytoplasmic)
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC37529010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 375M-94 |
| 0.5 mL concentrate | 375M-95 |
| 1.0 mL concentrate | 375M-96 |
| 1.0 mL predilute ready-to-use | 375M-97 |
| 7.0 mL predilute ready-to-use | 375M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 375M-94 |
| 0.5 mL concentrate | 375M-95 |
| 1.0 mL concentrate | 375M-96 |
| 1.0 mL predilute ready-to-use | 375M-97 |
| 7.0 mL predilute ready-to-use | 375M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 375M-94 |
| 0.5 mL concentrate | 375M-95 |
| 1.0 mL concentrate | 375M-96 |
| 1.0 mL predilute ready-to-use | 375M-97 |
| 7.0 mL predilute ready-to-use | 375M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 375M-94-RUO |
| 0.5 mL concentrate (RUO) | 375M-95-RUO |
| 1.0 mL concentrate (RUO) | 375M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 375M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 375M-98-RUO |
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