CD4 (SP35) Rabbit Monoclonal Antibody

CD4
Interfollicular T-lymphocytes are highlighted by CD4 antibody in a cytoplasmic pattern. Note scattered intrafollicular T-cells also express CD4 antigen.

CD4 (SP35) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD4 is a 55-kD glycoprotein expressed on the surface of T-helper/regulatory T-cells, monocytes, macrophages, and dendritic cells. The majority of peripheral T-cell lymphomas are derived from the T-helper/regulatory cell subset so that most mature T-cell neoplasms are CD4+/CD8-. Anti-CD4 is used in the immunohistochemical staining of lymphoproliferative disorders to evaluate tumors with CD4 aberrant expression.1-3

  1. Leong AS-Y, Cooper K, Leong FJW-M. Manual of diagnostic antibodies for immunohistochemistry, 2nd edition 2003; Greenwich Medical Media Ltd. 2003; 65-7.
  2. Akiyama T, et al. CD8+, CD56+ (natural killer-like) T-cell lymphoma involving the small intestine with no evidence of enteropathy: clinicopathology and molecular study of five Japanese patients. Pathol Int. 2008; 58:626-34.
  3. Garcia-Herrera A, et al. Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome. J Clin Oncol. 2008; 26:3364-71.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: tonsil, lymph node
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate104R-14
0.5 mL concentrate104R-15
1 mL concentrate104R-16
1 mL predilute104R-17
7 mL predilute104R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate104R-14
0.5 mL concentrate104R-15
1 mL concentrate104R-16
1 mL predilute104R-17
7 mL predilute104R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate104R-14
0.5 mL concentrate104R-15
1 mL concentrate104R-16
1 mL predilute104R-17
7 mL predilute104R-18

For research use only (RUO) in Japan

0.1 mL concentrate104R-14-RUO
0.5 mL concentrate104R-15-RUO
1 mL concentrate104R-16-RUO
1 mL predilute104R-17-RUO
7 mL predilute104R-18-RUO

 

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