Chromogranin A (LK2H10) Mouse Monoclonal Antibody

Chromogranin A
Pancreatic islet cells are highlighted by chromogranin A antibody in a cytoplasmic reaction.

Chromogranin A (LK2H10) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, thyroid, and parathyroid.1-3 Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin.1-3 It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms.

  1. Fischer-Colbrie R, et al. Immunological studies on the distribution of chromogranin A and B in endocrine and nervous tissues. Neuroscience. 1985; 16:547-55.
  2. Hearn SA. Electron microscopic localization of chromogranin A in osmium-fixed neuroendocrine cells with a protein A-gold technique. J Histochem Cytochem. 1987; 35:795-801.
  3. Wilson BS, et al. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol. 1984; 115:458-68.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: pancreas
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute238M-90
0.1 mL concentrate238M-94
0.5 mL concentrate238M-95
1 mL concentrate238M-96
1 mL predilute238M-97
7 mL predilute238M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute238M-90
0.1 mL concentrate238M-94
0.5 mL concentrate238M-95
1 mL concentrate238M-96
1 mL predilute238M-97
7 mL predilute238M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute238M-90
0.1 mL concentrate238M-94
0.5 mL concentrate238M-95
1 mL concentrate238M-96
1 mL predilute238M-97
7 mL predilute238M-98

For research use only (RUO) in Japan

25 mL predilute238M-90-RUO
0.1 mL concentrate238M-94-RUO
0.5 mL concentrate238M-95-RUO
1 mL concentrate238M-96-RUO
1 mL predilute238M-97-RUO
7 mL predilute238M-98-RUO

 

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