CD14 (EPR3653) Rabbit Monoclonal Antibody

CD14
Rabbit monoclonal anti-CD14 shows a moderate cytoplasmic staining reaction in macrophages and follicular dendritic cells.

CD14 (EPR3653) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD14 is a 55kDa glycosyl-phosphatidylinositol-linked membrane protein, involved in endotoxin binding and recognition of apoptotic cells.1 CD14 is expressed on monocytes, macrophages, follicular dendritic cells, and granulocytes.2-4 Anti-CD14 can detect these cells, including monocyte-derived cells which are frequently increased in diffuse large B-cell lymphoma (DLBCL),3 as well as in neoplastic cells in acute myeloid leukemia with monocytic differentiation and chronic myelomonocytic leukemia.5 

  1. Gregory CD, et al. CD14 and apoptosis. Apoptosis. 1999; 4:11-20.
  2. Wright SD, et al. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 1990; 249: 1431-33.
  3. Marmey B, et al. CD14 and CD169 expression in human lymph nodes and spleen: specific expansion of CD14+CD169- monocyte-derived cells in diffuse large B-cell lymphomas. Hum Pathol. 2006; 37:68-77.
  4. Smeltzer JP, et al. Pattern of CD14+ Follicular Dendritic Cells and PD1+ T Cells Independently Predicts Time to Transformation in Follicular Lymphoma. Clin Cancer Res. 2014; 20:2862-72.
  5. Rollins-Raval MA, et al. The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias. Histopathology. 2012; 60: 933-42.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil, lymph node, appendix, colon, myeloid leukemia
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate114R-14
0.5 mL concentrate114R-15
1 mL concentrate114R-16
1 mL predilute114R-17
7 mL predilute114R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate114R-14
0.5 mL concentrate114R-15
1 mL concentrate114R-16
1 mL predilute114R-17
7 mL predilute114R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate114R-14
0.5 mL concentrate114R-15
1 mL concentrate114R-16
1 mL predilute114R-17
7 mL predilute114R-18

For research use only (RUO) in Japan

0.1 mL concentrate114R-14-RUO
0.5 mL concentrate114R-15-RUO
1 mL concentrate114R-16-RUO
1 mL predilute114R-17-RUO
7 mL predilute114R-18-RUO

 

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