CD1a (EP3622) Rabbit Monoclonal Antibody

CD1a
Rabbit monoclonal anti-CD1a shows strong cytoplasmic staining in thymic cortical lymphocytes.

CD1a (EP3622) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-26 11:39:59

CD1a is a non-polymorphic, major histocompatibility complex, class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with β-microglobulin.1 In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating cells, and rare antigen-presenting cells of the lymph node.2 CD1a positivity has also been seen in Langerhans cell histiocytosis (histiocytosis X)3, and a subset of pre-T lymphoblastic lymphoma/leukemia (cortical T LBL/L).4,5

  1. Krenacs L, et al. Immunohistochemical detection of CD1A antigen in formalin-fixed and paraffin-embedded tissue sections with monoclonal antibody 010. J Pathol. 1993; 171:99-104.
  2. Angel CE, et al. Distinctive localization of antigen-presenting cells in human lymph nodes. Blood. 2009; 113:1257-67.
  3. Emile JF, et al. Langerhans' cell histiocytosis. Definitive diagnosis with the use of monoclonal antibody O10 on routinely paraffin-embedded samples. Am J Surg Pathol. 1995; 19:636-41.
  4. Stefano, AP et al. Acute leukemia immunophenotyping in bone-marrow routine sections. Br J Haematol. 1999; 105:394-401.
  5. Han X, et al. Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. Am J Clin Pathol. 2007; 127:528-44.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: skin, thymus
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate101R-14
0.5 mL concentrate101R-15
1 mL concentrate101R-16
1 mL predilute101R-17
7 mL predilute101R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate101R-14
0.5 mL concentrate101R-15
1 mL concentrate101R-16
1 mL predilute101R-17
7 mL predilute101R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate101R-14
0.5 mL concentrate101R-15
1 mL concentrate101R-16
1 mL predilute101R-17
7 mL predilute101R-18

For research use only (RUO) in Japan

0.1 mL concentrate101R-14-RUO
0.5 mL concentrate101R-15-RUO
1 mL concentrate101R-16-RUO
1 mL predilute101R-17-RUO
7 mL predilute101R-18-RUO

 

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