CD163 (MRQ-26) Mouse Monoclonal Antibody
Specialties: Hematopathology
CD163, also known as scavenger receptor cysteine-rich type 1 protein M130,1 is an acute phase-regulated and signal-inducing transmembrane protein,2 found exclusively on cells of monocytic origin.1 CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes.2 Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin.3 Anti-CD163 labels cells of monocytic-macrophage lineage, with expression in bone marrow3 and histiocytic neoplasms.4
- Buechler C, et al. Regulation of scavenger receptor CD163 expression in human monocytes and macrophagesby pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67:97-103.
- Kristiansen M, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001; 409:198-201.
- Etzerodt A, et al. CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal. 2013; 18: 2352-63.
- Backe E, Schwarting R, Gerdes J, et al. Ber-MAC3: new monoclonal antibody that defines human monocyte/macrohphage differentiation antigen. J Clin Pathol. 1991; 44:936-45.
Specifications
- Reactivity: paraffin
- Control: Inflamed Tissue (Cytoplasmic, Membranous)
- Dilution Range: 1:10-1:50 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC16321050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 163M-14 |
| 0.5 mL concentrate | 163M-15 |
| 1.0 mL concentrate | 163M-16 |
| 1.0 mL predilute ready-to-use | 163M-17 |
| 7.0 mL predilute ready-to-use | 163M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 163M-14 |
| 0.5 mL concentrate | 163M-15 |
| 1.0 mL concentrate | 163M-16 |
| 1.0 mL predilute ready-to-use | 163M-17 |
| 7.0 mL predilute ready-to-use | 163M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 163M-14 |
| 0.5 mL concentrate | 163M-15 |
| 1.0 mL concentrate | 163M-16 |
| 1.0 mL predilute ready-to-use | 163M-17 |
| 7.0 mL predilute ready-to-use | 163M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 163M-14-RUO |
| 0.5 mL concentrate (RUO) | 163M-15-RUO |
| 1.0 mL concentrate (RUO) | 163M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 163M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 163M-18-RUO |
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