CD21 (EP3093) Rabbit Monoclonal Antibody

CD21
Germinal center and interfollicular B-cells are highlighted by rabbit monoclonal anti-CD21 in a membranous pattern.

CD21 (EP3093) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDa membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells.1 The antigen is absent on T-lymphocytes, monocytes, and granulocytes.2,3

Anti-CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas.2,4,5 Anti-CD21 is valuable in differentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphoma with follicular involvement. It also plays a role in distinguishing among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers.6 Anti-CD21 is also useful in identifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma.7

  1. Cheuk W, et al. Am J Surg Pathol. 2001; 25:721-31.
  2. Pileri SA, et al. Histopathology. 2002; 41:1-29.
  3. Maeda K, et al. 2002; 50:1475-1485.
  4. Biddle DA, et al. Mod Pathol. 2002; 15:50-58.
  5. Chan AC, et al. Histopathology. 2001; 38:510-8.
  6. Chang KC, et al. J Pathol. 2003; 201:404-12.
  7. Chuang SS, et al. Int J Hematol. 2010; 91:687-91.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate121R-14
0.5 mL concentrate121R-15
1 mL concentrate121R-16
1 mL predilute121R-17
7 mL predilute121R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate121R-14
0.5 mL concentrate121R-15
1 mL concentrate121R-16
1 mL predilute121R-17
7 mL predilute121R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate121R-14
0.5 mL concentrate121R-15
1 mL concentrate121R-16
1 mL predilute121R-17
7 mL predilute121R-18

For research use only (RUO) in Japan

0.1 mL concentrate121R-14-RUO
0.5 mL concentrate121R-15-RUO
1 mL concentrate121R-16-RUO
1 mL predilute121R-17-RUO
7 mL predilute121R-18-RUO

 

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