CD21 (EP3093) Rabbit Monoclonal Antibody
Specialties: Hematopathology
CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDa membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells.1 The antigen is absent on T-lymphocytes, monocytes, and granulocytes.2,3
Anti-CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas.2,4,5 Anti-CD21 is valuable in differentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphoma with follicular involvement. It also plays a role in distinguishing among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers.6 Anti-CD21 is also useful in identifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma.7
- Cheuk W, et al. Am J Surg Pathol. 2001; 25:721-31.
- Pileri SA, et al. Histopathology. 2002; 41:1-29.
- Maeda K, et al. 2002; 50:1475-1485.
- Biddle DA, et al. Mod Pathol. 2002; 15:50-58.
- Chan AC, et al. Histopathology. 2001; 38:510-8.
- Chang KC, et al. J Pathol. 2003; 201:404-12.
- Chuang SS, et al. Int J Hematol. 2010; 91:687-91.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: lymph node, tonsil
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC12131040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 121R-14 |
| 0.5 mL concentrate | 121R-15 |
| 1 mL concentrate | 121R-16 |
| 1 mL predilute | 121R-17 |
| 7 mL predilute | 121R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 121R-14 |
| 0.5 mL concentrate | 121R-15 |
| 1 mL concentrate | 121R-16 |
| 1 mL predilute | 121R-17 |
| 7 mL predilute | 121R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 121R-14 |
| 0.5 mL concentrate | 121R-15 |
| 1 mL concentrate | 121R-16 |
| 1 mL predilute | 121R-17 |
| 7 mL predilute | 121R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 121R-14-RUO |
| 0.5 mL concentrate | 121R-15-RUO |
| 1 mL concentrate | 121R-16-RUO |
| 1 mL predilute | 121R-17-RUO |
| 7 mL predilute | 121R-18-RUO |
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