Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody

Cytokeratin 5 & 6
Cytokeratin 5 & 6 antibody labels mesothelioma cells in a cytoplasmic pattern.

Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Twenty identified cytokeratins make up a complex family of  intermediate filaments.Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.1

  1. Ordóñez NG1. Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am J Surg Pathol. 1998; 22:1215-1221.
  2. Takahashi K, et al. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J Biol Chem. 1995; 270:18581-92.
  3. Lersch R, et al. Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol. 1989; 9:3685-97.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: mesothelioma
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute356M-10
0.1 mL concentrate356M-14
0.5 mL concentrate356M-15
1 mL concentrate356M-16
1 mL predilute356M-17
7 mL predilute356M-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute356M-10
0.1 mL concentrate356M-14
0.5 mL concentrate356M-15
1 mL concentrate356M-16
1 mL predilute356M-17
7 mL predilute356M-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute356M-10
0.1 mL concentrate356M-14
0.5 mL concentrate356M-15
1 mL concentrate356M-16
1 mL predilute356M-17
7 mL predilute356M-18

For research use only (RUO) in Japan

25 mL predilute356M-10-RUO
0.1 mL concentrate356M-14-RUO
0.5 mL concentrate356M-15-RUO
1 mL concentrate356M-16-RUO
1 mL predilute356M-17-RUO
7 mL predilute356M-18-RUO

 

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Literature

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