hnRNP K (EP330) Rabbit Monoclonal Antibody
Heterogeneous nucleus ribonucleoprotein (hnRNP) K is a component of the hnRNP complex, encoding for a 464 amino acid protein that mediates DNA and RNA binding. It is involved in the transcription, splicing and translation processes and recently implicated in tumorigenesis. Several oncogenes, such as c-Src, eIF4E and c-myc are regulated by hnRNP K. Correlation between elevated expression of hnRNP K and tumor development and progression are well documented. It has also been found to enhance cell proliferation and neoplastic transformation.
In normal tissues, hnRNP K is present primarily in the nucleus. Nuclear and aberrant cytoplasmic overexpression have been described in colorectal, prostate, hepatic, esophageal, and breast cancers that have been significantly associated with poor prognosis.
Specifications
- Reactivity: paraffin
- Visualization: nuclear, cytoplasmic
- Control: Hepatocellular carcinoma
- Dilution Range: 1:100 - 1:200*
Package Inserts
IFU:
IFU included with product
SDS:
Download your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
1 mL concentrate | AC-0305 |
0.1 mL concentrate | AC-0305A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
1 mL concentrate | AC-0305 |
0.1 mL concentrate | AC-0305A |
For research use only (RUO) in Japan
1 mL concentrate | AC-0305 |
0.1 mL concentrate | AC-0305A |
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