COX-2 (EP293) Rabbit Monoclonal Antibody
COX-2, also known as prostaglandin-endoperoxidase synthase 2 (PTGS2), is an immediate-early gene that encodes a critical enzyme for the conversion of arachidonic acids to prostaglandins. Functionally, COX-2 exists as a homodimer, consisting of two 70kDa subunits. COX-2 derived prostanoids have been shown to increase resistance to apoptosis, promote angiogenesis, induce metastasis and invasion, and impair immune surveillance.
Immunohistochemical expression of COX-2 has been described in multiple tissue types. While COX-2 expression is limited in most normal tissues, it is induced by various stimuli and elevated during inflammatory responses. Reports have associated COX-2 expression with cancers from multiple tissues. Lung, colon, gastric, prostate, and breast carcinomas were described to have elevated levels of COX-2. Further, elevated COX-2 levels has been associated with poor prognosis and decreased survival in patients with breast cancer.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: Colon carcinoma
- Dilution Range: 1:100 - 1:200*
Package Inserts
IFU:
IFU included with product
SDS:
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Ordering Information
For in vitro diagnostic (IVD) use in USA
1 mL concentrate | AC-0273 |
0.1 mL concentrate | AC-0273A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
1 mL concentrate | AC-0273 |
0.1 mL concentrate | AC-0273A |
For research use only (RUO) in Japan
1 mL concentrate | AC-0273 |
0.1 mL concentrate | AC-0273A |
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