TCL1 (EP105) Rabbit Monoclonal Antibody

Tonsil stained with anti-TCL1

TCL1 (EP105) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

T-cell leukemia/lymphoma protein 1A (TCL1) is a member of the TCL1 family and enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. TCL1 promotes the nuclear translocation of AKT1 and enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. The expression of TCL1 is restricted to lymphoid cells. It is expressed early in lymphocyte differentiation. Strong expression of TCL1 is found in a subset of mantle zone B lymphocytes and is expressed to a lesser extent by follicle center cells. In B-cell neoplasia, TCL1 immunoreactivity is found in the majority of B-cell lymphomas including lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, Burkitt lymphoma, diffuse large B-cell lymphoma (60%), and primary cutaneous B-cell lymphoma (55%). The expression of the TCL1 gene characterizes low-grade B-cell lymphomas.


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: tonsil, B-cell lymphoma
  • Dilution Range: 1:100 - 1:200*

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IFU included with product

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Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL concentrateAC-0110
0.1 mL concentrateAC-0110A

This product is not available in Canada

For in vitro diagnostic (IVD) use in Europe

1 mL concentrateAC-0110
0.1 mL concentrateAC-0110A

For research use only (RUO) in Japan

1 mL concentrateAC-0110
0.1 mL concentrateAC-0110A


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