TBX21 (T-bet) (EP263) Rabbit Monoclonal Antibody

TBX21 (T-bet)
Hodgkin?s lymphoma stained with anti-TBX21 (T-bet)

TBX21 (T-bet) (EP263) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

T-box transcription factor TBX21, also known as T-bet, is a member of the T-box family of transcription factors. It has been confirmed that TBX21 is the key lineage-defining transcription factor that directs the development Th1 cells and is directly responsible for the transactivation of the interferon-γ (IFN-γ) gene. TBX21 is expressed in CD4+ T lymphocytes in normal tissues. In lymphoid malignancies, TBX21 has been found in a subset of T-cell lymphomas with Th1 T-cell differentiation, a subset of B-cell or T cells, non-Hodgkin's lymphomas, majority of Hodgkin's lymphomas and precursor B-cell lymphoblastic leukemia/lymphoblastic lymphomas. However, TBX21 is not expressed in diffuse large B-cell lymphoma and most cases of anaplastic large cell lymphoma. TBX21 is a useful new marker for Hodgkin's lymphoma. TBX21 is also helpful in identification of hairy cell leukemia (HCL).


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: spleen, Hodgkin's lymphoma
  • Dilution Range: 1:100 - 1:200*

Package Inserts

IFU included with product

Download your SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL concentrateAC-0240
0.1 mL concentrateAC-0240A

This product is not available in Canada

For in vitro diagnostic (IVD) use in Europe

1 mL concentrateAC-0240
0.1 mL concentrateAC-0240A

For research use only (RUO) in Japan

1 mL concentrateAC-0240
0.1 mL concentrateAC-0240A


To request information on this product in additional countries, please click the button below.

Request More Information