OCT-4 (EP143) Rabbit Monoclonal Antibody

Seminoma stained with anti-OCT-4

OCT-4 (EP143) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

OCT-4, also known as OTF3 or POU5F1, is a member of the POU family of transcription factors, involved in the regulation of pluripotency during normal development and is detectable in embryonic stem and germ cells. It can specifically bind to the octamer motif (5'-ATTTCAT-3'), and it is critical for the self-renewal of embryonic stem cells. Overall, OCT-4 is a key regulator of self-renewal in embryonic stem cells; its expression is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. OCT-4 is expressed in undifferentiated pluriopotency cells, germ cells in ovary and testes. OCT-4 is a sensitive and specific marker for germ cell tumors. It is consistently detected in carcinoma in situ/gonadoblastoma, seminomas, germinoma, dysgerminoma, and embryonal carcinoma but not in the differentiated components of nonseminomas, i.e., teratomas, yolk sac tumors, and choriocarcinomas. An antibody to OCT-4 is useful in the identification of primary as well as metastatic germ cell tumors.


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: seminoma
  • Dilution Range: 1:100 - 1:200*

Package Inserts

IFU included with product

Download your SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL concentrateAC-0128
0.1 mL concentrateAC-0128A

This product is not available in Canada

For in vitro diagnostic (IVD) use in Europe

1 mL concentrateAC-0128
0.1 mL concentrateAC-0128A

For research use only (RUO) in Japan

1 mL concentrateAC-0128
0.1 mL concentrateAC-0128A


To request information on this product in additional countries, please click the button below.

Request More Information