MUM1 (EP190) Rabbit Monoclonal Antibody
MUM1 (multiple myeloma oncogene-1, also called IRF4), a member of the IRF family transcriptional factors, is induced by antigen receptor mediated stimuli and plays a crucial role in cell proliferation, differentiation and survival. In the hematolymphoid system, MUM1 is primarily expressed in B cells and actived T-lymphoid cells. In B cells, it is expressed on a small subset of germinal center (GC) cells committed to plasmacytic or memory cell differentiation in the "light zone" and in plasma cells. MUM1 has been identified as a marker of non-germinal center-derived DLBCL, a subtype also associated with more aggressive clinical behavior and poor prognosis, but absent in mantle cell lymphoma (pre-GC B cells) and in follicular lymphoma (GC B cells). MUM1 may be a potential histo-genetic marker for B-cell lymphomas. Additionally, MUM1 is a useful marker for Reed-Sternberg (HRS) cells in Hodgkin's lymphoma.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, nuclear
- Control: tonsil, plasmacytoma
- Dilution Range: 1:100 - 1:200*
Package Inserts
IFU:
IFU included with product
SDS:
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Ordering Information
For in vitro diagnostic (IVD) use in USA
1 mL concentrate | AC-0186 |
0.1 mL concentrate | AC-0186A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
1 mL concentrate | AC-0186 |
0.1 mL concentrate | AC-0186A |
For research use only (RUO) in Japan
1 mL concentrate | AC-0186 |
0.1 mL concentrate | AC-0186A |
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