
IMP-3 (EP286) Rabbit Monoclonal Antibody
IMP-3, known as Insulin-like growth factor 2 (IGF-II) mRNA-binding protein 3, is an oncofetal protein that stabilizes IGF-II mRNA for trafficking and plays an important role in cell growth and migration. This 65-70 kDa protein is expressed normally in developing tissues during early embryogenesis in a variety of fetal tissues including the liver, lung kidney, thymus, and placenta, but at low or undetectable levels in normal adult tissues. Recent studies have demonstrated IMP-3 expression in various malignant tumors of the lung, gastrointestinal tract, liver, endometrium, and bladder, while undetectable in adjacent benign tissues. IMP-3 may have a critical role in tumor proliferation, invasion and metastasis, and has been suggested to be an independent marker for poor prognosis in patients with clear cell carcinomas.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, nuclear
- Control: fetal liver, esophageal carcinoma
- Dilution Range: 1:100-1:200*
Package Inserts
IFU:
IFU included with product
SDS:
Download your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
1 mL concentrate | AC-0266 |
0.1 mL concentrate | AC-0266A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
1 mL concentrate | AC-0266 |
0.1 mL concentrate | AC-0266A |
For research use only (RUO) in Japan
1 mL concentrate | AC-0266 |
0.1 mL concentrate | AC-0266A |
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