Claudin-5 (EP224) Rabbit Monoclonal Antibody
Claudin-5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin-5 have been found in patients with velocardiofacial syndrome. Claudin-5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin-5 is also found in bronchial and lung epithelial cells. In tumors, Claudn-5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior.
Specifications
- Reactivity: paraffin
- Visualization: cell junction/membranous
- Control: vascular tissue
- Dilution Range: 1:100 - 1:200*
Package Inserts
IFU:
IFU included with product
SDS:
Download your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
1 mL concentrate | AC-0212 |
0.1 mL concentrate | AC-0212A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
1 mL concentrate | AC-0212 |
0.1 mL concentrate | AC-0212A |
For research use only (RUO) in Japan
1 mL concentrate | AC-0212 |
0.1 mL concentrate | AC-0212A |
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