CD25 (EP218) Rabbit Monoclonal Antibody
CD25, or interleukin 2 (IL2) receptor alpha (IL2RA), and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (CD25) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble CD25 has been isolated and determined to result from extracellular proteolyisis. CD25 (the p55 chain of the interleukin-2 receptor) is a marker of activation for a number of cell types, including T cells, B cells, and macrophages. It also appears to be a reliable immunohistochemical marker for the discrimination of neoplastic from normal/reactive mast cells, with potential as a diagnostic tool in systemic mastocytosis. CD25 is also expressed on hairy cell leukemia.
Specifications
- Reactivity: paraffin
- Visualization: membrane
- Control: tonsil, mastocytosis
- Dilution Range: 1:100 - 1:200*
Package Inserts
IFU:
IFU included with product
SDS:
Download your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 1 mL concentrate | AC-0209 |
| 0.1 mL concentrate | AC-0209A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
| 1 mL concentrate | AC-0209 |
| 0.1 mL concentrate | AC-0209A |
For research use only (RUO) in Japan
| 1 mL concentrate | AC-0209 |
| 0.1 mL concentrate | AC-0209A |
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