
CD105 (EP274) Rabbit Monoclonal Antibody
CD105 (endoglin) is a disulfide-linked homodimeric cell membrane glycoprotein. It was initially discovered in a human pre-B-cell line. CD105 functions as a receptor for transforming growth factor (TGF) -β1 and -β3, and modulates TGF-β signaling through interactions with TGF-β receptors 1 and/or 2. CD105 is a proliferation-associated and hypoxia-inducible protein abundantly expressed in angiogenic endothelial cells. Tumor microvessel density assessed by CD105 immunohistochemical staining in paraffin-embedded tissue sections correlates significantly with tumor aggressiveness and prognosis in many types solid tumors.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: vascular tissue
- Dilution Range: 1:100 - 1:200*
Package Inserts
IFU:
IFU included with product
SDS:
Download your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
1 mL concentrate | AC-0243 |
0.1 mL concentrate | AC-0243A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
1 mL concentrate | AC-0243 |
0.1 mL concentrate | AC-0243A |
For research use only (RUO) in Japan
1 mL concentrate | AC-0243 |
0.1 mL concentrate | AC-0243A |
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