c-Myc (EP121) Rabbit Monoclonal Antibody

Lung cancer stained with anti-c-Myc

c-Myc (EP121) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

The c-Myc gene is located at chromosome 8q24. It is required for progression through the cell cycle and promotes cellular proliferation. The t(8;14)(q24;q32) translocation and the c-Myc/immunoglobulin heavy-chain (IGH) fusion gene are not only in Burkitt lymphoma, but are also seen in diffuse large B-cell lymphoma, blastic mantle cell lymphoma and transformed follicular lymphoma. In another study on predicting c-Myc translocation in 17 cases of Burkitt lymphomas (BLs) and 19 cases of diffuse large B-cell lymphomas (DLBCLs), Ruzinova et al. reported that the sensitivity and specificity of this c-Myc antibody on identifying tumors harboring a c-Myc rearrangement reached 96% and 90% respectively. This novel c-Myc antibody is a useful tool for identifying aggressive B-cell lymphomas likely to harbor a c-Myc rearrangement, and thus warrant genetic testing.


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: Burkitt's lymphoma
  • Dilution Range: 1:100 - 1:200*

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Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL concentrateAC-0116
0.1 mL concentrateAC-0116A

This product is not available in Canada

For in vitro diagnostic (IVD) use in Europe

1 mL concentrateAC-0116
0.1 mL concentrateAC-0116A

For research use only (RUO) in Japan

1 mL concentrateAC-0116
0.1 mL concentrateAC-0116A


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