Aurora B (EP136) Rabbit Monoclonal Antibody
The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: tonsil, colon carcinoma
- Dilution Range: 1:20*
Package Inserts
IFU:
IFU included with product
SDS:
Download your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
1 mL concentrate | AC-0196 |
0.1 mL concentrate | AC-0196A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
1 mL concentrate | AC-0196 |
0.1 mL concentrate | AC-0196A |
For research use only (RUO) in Japan
1 mL concentrate | AC-0196 |
0.1 mL concentrate | AC-0196A |
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