Cell Marque Portfolio

Podoplanin (D2-40)

Mouse Monoclonal


Podoplanin is a transmembrane mucoprotein (38kD) recognized by the D2-40 monoclonal antibody.1 Podoplanin is selectively expressed in lymphatic endothelium1-6 as well as lymphangiomas,7 Kaposi sarcomas,6,8 and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.1,9,10

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Isotype: IgG1
  • Dilution Range: 1:20-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER1/30

Package Inserts


IFU SDS

References


  1. Ordonez N. Adv Anat Pathol. 2006; 13:83-8.
  2. Niakosari F, et al. Arch Dermatol. 2005; 141:440-4.
  3. Galambos C, et al. Pediatr Dev Pathol. 2005; 8:191-9.
  4. Fukunaga M. Histopathology. 2005; 46:396-402.
  5. Fogt F, et al. Oncol Rep. 2004; 11:47-50.
  6. Kahn HJ, et al. Mod Pathol. 2002; 15:434-40.
  7. Franke FE, et al. J Cutan Pathol. 2004; 31:362-7.
  8. Kalof AN,et al. Adv Anat Pathol. 2009; 16:62-4.
  9. Chu AY, et al. Mod Pathol. 2005; 18:105-10.
  10. Iczkowski KA, et al. Human Pathology. 2008; 39:275–281.

Literature

Last updated: 2017-05-24 08:46:09

Podoplanin
Abundant cytoplasmic labelling on seminoma by podoplanin antibody.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Isotype: IgG1
  • Dilution Range: 1:20-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER1/30

References


  1. Ordonez N. Adv Anat Pathol. 2006; 13:83-8.
  2. Niakosari F, et al. Arch Dermatol. 2005; 141:440-4.
  3. Galambos C, et al. Pediatr Dev Pathol. 2005; 8:191-9.
  4. Fukunaga M. Histopathology. 2005; 46:396-402.
  5. Fogt F, et al. Oncol Rep. 2004; 11:47-50.
  6. Kahn HJ, et al. Mod Pathol. 2002; 15:434-40.
  7. Franke FE, et al. J Cutan Pathol. 2004; 31:362-7.
  8. Kalof AN,et al. Adv Anat Pathol. 2009; 16:62-4.
  9. Chu AY, et al. Mod Pathol. 2005; 18:105-10.
  10. Iczkowski KA, et al. Human Pathology. 2008; 39:275–281.

Package Inserts

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute 322M-10
0.1 mL concentrate 322M-14
0.5 mL concentrate 322M-15
1 mL concentrate 322M-16
1 mL predilute 322M-17
7 mL predilute 322M-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute 322M-10
0.1 mL concentrate 322M-14
0.5 mL concentrate 322M-15
1 mL concentrate 322M-16
1 mL predilute 322M-17
7 mL predilute 322M-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute 322M-10
0.1 mL concentrate 322M-14
0.5 mL concentrate 322M-15
1 mL concentrate 322M-16
1 mL predilute 322M-17
7 mL predilute 322M-18

For research use only (RUO) in Japan

25 mL predilute 322M-10-RUO
0.1 mL concentrate 322M-14-RUO
0.5 mL concentrate 322M-15-RUO
1 mL concentrate 322M-16-RUO
1 mL predilute 322M-17-RUO
7 mL predilute 322M-18-RUO

 

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Literature

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Isotype: IgG1
  • Dilution Range: 1:20-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER1/30

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References


  1. Ordonez N. Adv Anat Pathol. 2006; 13:83-8.
  2. Niakosari F, et al. Arch Dermatol. 2005; 141:440-4.
  3. Galambos C, et al. Pediatr Dev Pathol. 2005; 8:191-9.
  4. Fukunaga M. Histopathology. 2005; 46:396-402.
  5. Fogt F, et al. Oncol Rep. 2004; 11:47-50.
  6. Kahn HJ, et al. Mod Pathol. 2002; 15:434-40.
  7. Franke FE, et al. J Cutan Pathol. 2004; 31:362-7.
  8. Kalof AN,et al. Adv Anat Pathol. 2009; 16:62-4.
  9. Chu AY, et al. Mod Pathol. 2005; 18:105-10.
  10. Iczkowski KA, et al. Human Pathology. 2008; 39:275–281.
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