Podoplanin (D2-40) Mouse Monoclonal Antibody

Podoplanin
Abundant cytoplasmic labelling on seminoma by podoplanin antibody.

Podoplanin (D2-40) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2018-01-24 14:35:27

Podoplanin is a transmembrane mucoprotein (38 kD) recognized by the D2-40 monoclonal antibody. Podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, and Kaposi sarcomas. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas  and seminomas.1-9

  1. Ordóñez NG. Podoplanin: a novel diagnostic immunohistochemical marker. Adv Anat Pathol. 2006; 13:83-8.
  2. Ordóñez N. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol. 2005; 36:372-80.
  3. Niakosari F, et al. Detection of lymphatic invasion in primary melanoma with monoclonal antibody D2-40: a new selective immunohistochemical marker of lymphatic endothelium. Arch Dermatol. 2005; 141:440-4.
  4. Galambos C, et al. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Pediatr Dev Pathol. 2005; 8:181-9.
  5. Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology. 2005; 46:396-402.
  6. Chu AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol. 2005; 18:105-10.
  7. Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol. 2004; 31:362-7.
  8. Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep. 2004; 11:47-50.
  9. Kahn HJ, et al. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002; 15:434-40.

Specifications


  • Reactivity: paraffin
  • Control: Tonsil (Cytoplasmic)
  • Dilution Range: 1:20-1:100 *

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25.0 mL predilute ready-to-use322M-10
0.1 mL concentrate322M-14
0.5 mL concentrate322M-15
1.0 mL concentrate322M-16
1.0 mL predilute ready-to-use322M-17
7.0 mL predilute ready-to-use322M-18

For in vitro diagnostic (IVD) use in Canada

25.0 mL predilute ready-to-use322M-10
0.1 mL concentrate322M-14
0.5 mL concentrate322M-15
1.0 mL concentrate322M-16
1.0 mL predilute ready-to-use322M-17
7.0 mL predilute ready-to-use322M-18

For in vitro diagnostic (IVD) use in Europe

25.0 mL predilute ready-to-use322M-10
0.1 mL concentrate322M-14
0.5 mL concentrate322M-15
1.0 mL concentrate322M-16
1.0 mL predilute ready-to-use322M-17
7.0 mL predilute ready-to-use322M-18

For research use only (RUO) in Japan

25.0 mL predilute ready-to-use (RUO)322M-10-RUO
0.1 mL concentrate (RUO)322M-14-RUO
0.5 mL concentrate (RUO)322M-15-RUO
1.0 mL concentrate (RUO)322M-16-RUO
1.0 mL predilute ready-to-use (RUO)322M-17-RUO
7.0 mL predilute ready-to-use (RUO)322M-18-RUO

 

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