CD57 (NK-1) Mouse Monoclonal Antibody

CD57
Intrafollicular NK cells are positive for CD57.

CD57 (NK-1) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD57, also known as HNK-1 (human natural killer-1), is a cell surface carbohydrate epitope expressed on terminally differentiated T-cells and subsets of natural killer (NK) cells.1 It has also been identified on cells of neural crest origin.2 Anti-CD57 is often used to visualize the non-neoplastic bystander T-cells that may form rosettes around the neoplastic lymphocyte-predominant (LP) cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).3

  1. Kared H, et al. CD57 in human natural killer cells and T-lymphocytes. Cancer Immunol Immunother. 2016; 65:441-52.
  2. Nielsen CM, et al. Functional significance of CD57 expression on human NK cells and relevance to disease. Front Immunol. 2013; 4:422.
  3. Sattarzadeh A, et al. CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma. Exp Hematol Oncol. 2015; 4:27.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate157M-94
0.5 mL concentrate157M-95
1 mL concentrate157M-96
1 mL predilute157M-97
7 mL predilute157M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate157M-94
0.5 mL concentrate157M-95
1 mL concentrate157M-96
1 mL predilute157M-97
7 mL predilute157M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate157M-94
0.5 mL concentrate157M-95
1 mL concentrate157M-96
1 mL predilute157M-97
7 mL predilute157M-98

For research use only (RUO) in Japan

0.1 mL concentrate157M-94-RUO
0.5 mL concentrate157M-95-RUO
1 mL concentrate157M-96-RUO
1 mL predilute157M-97-RUO
7 mL predilute157M-98-RUO

 

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