SALL4 (EP299) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Genitourinary (GU) Pathology
Sal-like protein 4 (SALL4) is a zinc-finger transcription factor1 that serves as a master regulator of embryonic pluripotency and is involved in processes associated with stem cell activities.2 SALL4 expression in germ cells makes it a useful marker for germ cell tumors such as seminoma, embryonal carcinoma, yolk sac tumors and teratomas.1 SALL4 expression is also seen in the spermatogonia of normal testis.
Note: This product is in obsolescence. SALL4 (6E3) is available as an alternative.
- Miettinen M, et al. SALL4 expression in germ cell and non-germ cell tumors: a systematic immunohistochemical study of 3215 cases. Am J Surg Pathol. 2014; 38:410-20.
- Yang J, et al. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. PNAS. 2008; 105:19756-61.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: seminoma, dysgerminoma
- Dilution Range: 1:20-1:100*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC38531020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 385R-14 |
| 0.5 mL concentrate | 385R-15 |
| 1 mL concentrate | 385R-16 |
| 1 mL predilute | 385R-17 |
| 7 mL predilute | 385R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 385R-14 |
| 0.5 mL concentrate | 385R-15 |
| 1 mL concentrate | 385R-16 |
| 1 mL predilute | 385R-17 |
| 7 mL predilute | 385R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 385R-14 |
| 0.5 mL concentrate | 385R-15 |
| 1 mL concentrate | 385R-16 |
| 1 mL predilute | 385R-17 |
| 7 mL predilute | 385R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 385R-14-RUO |
| 0.5 mL concentrate | 385R-15-RUO |
| 1 mL concentrate | 385R-16-RUO |
| 1 mL predilute | 385R-17-RUO |
| 7 mL predilute | 385R-18-RUO |
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