Actin, Muscle Specific (HHF35) Mouse Monoclonal Antibody

Actin, Muscle Specific
Actin, Muscle Specific (HHF35) on skeletal muscle.

Actin, Muscle Specific (HHF35) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

Muscle Specific Actin is a part of the actin family of proteins which are highly conserved, major components of the cytoskeleton. Anti-Muscle Specific Actin immunohistochemical reactivity is seen in skeletal, cardiac, and smooth muscle cells and can be seen in neoplasms with muscle differentiation such as leiomyomas and rhabdomyosarcomas. In contrast, anti-Muscle Specific Actin reactivity is typically not seen in endothelial cells, connective tissues, carcinomas, melanomas, lymphomas and most nonmyogenic sarcomas.1-5

  1. Gown AM, et al. Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol. 1986; 125:191.
  2. Schmidt RA, et al. Diagnosis of rhabdomyosarcomas with HHF35, a monoclonal antibody directed against muscle actins. Am J Pathol. 1988; 131:19-28.
  3. Azumi N, et al. Immunophenotypic diagnosis of leiomyosarcomas and rhabdomyosarcomas with monoclonal antibodies to muscle-specific actin and desmin in formalin-fixed tissue. Mod Pathol. 1988; 1:469-74.
  4. Rangdaeng S, et al. Comparative immunohistochemical staining for desmin and muscle-specific actin. A study of 576 cases. Am J Clin Pathol. 1991; 96:32-45.
  5. Tsukada T, et al. HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues. Am J Pathol. 1987; 127:389-402.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: skeletal muscle
  • Dilution Range: 1:10-1:50*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate201M-94
0.5 mL concentrate201M-95
1 mL concentrate201M-96
1 mL predilute201M-97
7 mL predilute201M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate201M-94
0.5 mL concentrate201M-95
1 mL concentrate201M-96
1 mL predilute201M-97
7 mL predilute201M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate201M-94
0.5 mL concentrate201M-95
1 mL concentrate201M-96
1 mL predilute201M-97
7 mL predilute201M-98

For research use only (RUO) in Japan

0.1 mL concentrate201M-94-RUO
0.5 mL concentrate201M-95-RUO
1 mL concentrate201M-96-RUO
1 mL predilute201M-97-RUO
7 mL predilute201M-98-RUO

 

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