Cell Marque Portfolio

TLE1 (1F5)

Mouse Monoclonal


Transducin-like enhancer of split 1 (TLE1) gene is a member of the TLE gene family and involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation.1 By immunohistochemistry in formalin-fixed, paraffin-embedded tissues, TLE1 expression (nuclear staining) has been found in 35 of 35 molecularly confirmed synovial sarcoma cases, and was rare to absent in the 73 other soft tissue tumors examined (positive staining was found only in 1 of 43 malignant peripheral nerve sheath tumors and 1 pleomorphic sarcoma).1 Anti-TLE1 was more sensitive and specific for synovial sarcoma than other currently available immunohistochemical markers including BCL2, epithelial membrane antigen and cytokeratins, and had a positive predictive value of 92% and a negative predictive value of 100% in this clinical setting.1 TLE1 overexpression by immunohistochemistry is a highly sensitive and specific biomarker for the diagnosis of synovial sarcoma in the group of otherwise unclassifiable high-grade sarcomas.1

Specialties: Soft Tissue Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: synovial sarcoma
  • Isotype: IgG2a
  • Dilution Range: 1:10-1:50*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

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TLE1
TLE1 antibody labels the nuclei in tumor cells of synovial sarcoma.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: synovial sarcoma
  • Isotype: IgG2a
  • Dilution Range: 1:10-1:50*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 401M-14
0.5 ml, concentrate 401M-15
1 ml, concentrate 401M-16
1 ml, predilute 401M-17
7 ml, predilute 401M-18

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 401M-14
0.5 ml, concentrate 401M-15
1 ml, concentrate 401M-16
1 ml, predilute 401M-17
7 ml, predilute 401M-18

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 401M-14
0.5 ml, concentrate 401M-15
1 ml, concentrate 401M-16
1 ml, predilute 401M-17
7 ml, predilute 401M-18

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 401M-14 (RUO)
0.5 ml, concentrate 401M-15 (RUO)
1 ml, concentrate 401M-16 (RUO)
1 ml, predilute 401M-17 (RUO)
7 ml, predilute 401M-18 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: synovial sarcoma
  • Isotype: IgG2a
  • Dilution Range: 1:10-1:50*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

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