Cell Marque Portfolio

GATA3 (L50-823)

Mouse Monoclonal


GATA3 (GATA binding protein 3 to DNA sequence [A/T]GATA[A/G]) is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types. GATA3 expression is primarily seen in breast carcinoma and urothelial carcinoma and only rarely found in tumors from other organs, such as endometrial endometrioid adenocarcinoma. GATA3 is expressed in all breast lobular carcinomas and 91% of invasive ductal carcinomas (grade I, 100%; grade II, 89% and grade III, 86%1-2). GATA3 expression seems to be lower in luminal B subtype breast carcinoma. It has also been reported that GATA3 expression is correlated with the status of ER, PR and Her2 in breast carcinoma1-2. GATA3 expression is found in urothelial carcinoma, especially in invasive and high grade tumors. Therefore, anti-GATA3 can be used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are a possibility.

Specialties: Anatomic Pathology Breast/Gynecological Pathology Genitourinary (GU) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: breast carcinoma, urothelial carcinoma
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER1/5

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GATA3
Mouse monoclonal anti-GATA3 demonstrates a strong diffuse and nuclear reaction in neoplastic cells of invasive ductal carcinoma of the breast.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: breast carcinoma, urothelial carcinoma
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER1/5

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 390M-14
0.5 ml, concentrate 390M-15
1 ml, concentrate 390M-16
1 ml, predilute 390M-17
7 ml, predilute 390M-18

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 390M-14
0.5 ml, concentrate 390M-15
1 ml, concentrate 390M-16
1 ml, predilute 390M-17
7 ml, predilute 390M-18

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 390M-14
0.5 ml, concentrate 390M-15
1 ml, concentrate 390M-16
1 ml, predilute 390M-17
7 ml, predilute 390M-18

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 390M-14
0.5 ml, concentrate 390M-15
1 ml, concentrate 390M-16
1 ml, predilute 390M-17
7 ml, predilute 390M-18

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: breast carcinoma, urothelial carcinoma
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER1/5

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

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