Thrombomodulin (1009) Mouse Monoclonal Antibody

Thrombomodulin
Membranous labelling of urothelial transitional cell carcinoma by thrombomodulin antibody.

Thrombomodulin (1009) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Thrombomodulin is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD) with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express thrombomodulin.1-3 Anti-thrombomodulin has demonstrated positivity in benign vascular tumors such as hemangioma and most malignant vascular tumors (Kaposi’s sarcoma and epitheliod hemangioendothelioma).1-2 Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors.1-2 There has also been recent interest in the use of anti-thrombomodulin as an immunohiostochemical marker for mesothelial cells and malignant mesotheliomas.3-8 Anti-thrombomodulin is immunoexpressed in a variety of other tumors including urothelial cell carcinomas.9,10

  1. Acebo E, et al. Thrombomodulin, calretinin and c-kit (CD117) expression in cardiac myxoma. Histol. Histopath. 2001; 16:1031-6.
  2. Appleton MA, et al. Thrombomodulin as a marker of vascular and lymphatic tumors. Histopathology. 1996; 29:153-7.
  3. Attanoos RL, et al. Mesothelioma-binding antibodies: Thrombomodulin, OV632 and HBME-1 and their use in the diagnosis of malignant mesothelioma. Histopathology. 1996; 29:209-15.
  4. Attanoos RL, et al. Malignant epitheliod mesothelioma: anti-mesothelial marker expression correlates with histological pattern. Histopathology. 2001; 39:584-8.
  5. Attanoos RL, et al. Primary thymic epithelial tumours of the pleura mimicking malignant mesothelioma. Histopathology. 2002; 41:42-9.
  6. Brown RW, et al. Multiple-marker immunohistochemical phenotypes distinguishing malignant pleural mesothelioma from pulmonary adenocarcinoma. Hum. Pathol. 1993; 24:347-54.
  7. Collins CL, et al. Thrombomodulin expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. Am. J. Pathol. 1992; 141:827-33.
  8. Doglioni C, et al. Calretinin: A novel immunocytochemical marker for mesothelioma. Am J Surg Pathol. 1996; 20:1037-46.
  9. Chuang AY, et al. Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. Am J Surg Pathol. 2007; 31:1246-55.
  10. Dabbs DJ. Diagnostic Immunohistochemistry; Theranostic and Genomic Applications. 3rd. Edition. Sauders Elsevier. 2010. p234-5.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: bladder, mesothelioma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate339M-14
0.5 mL concentrate339M-15
1 mL concentrate339M-16
1 mL predilute339M-17
7 mL predilute339M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate339M-14
0.5 mL concentrate339M-15
1 mL concentrate339M-16
1 mL predilute339M-17
7 mL predilute339M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate339M-14
0.5 mL concentrate339M-15
1 mL concentrate339M-16
1 mL predilute339M-17
7 mL predilute339M-18

For research use only (RUO) in Japan

0.1 mL concentrate339M-14-RUO
0.5 mL concentrate339M-15-RUO
1 mL concentrate339M-16-RUO
1 mL predilute339M-17-RUO
7 mL predilute339M-18-RUO

 

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