SOX-2 (SP76) Rabbit Monoclonal Antibody

SOX-2
Squamous cell carcinoma of lung is expressed by SOX-2 antibody in a nuclear pattern.

SOX-2 (SP76) Rabbit Monoclonal Antibody

Specialties: Pulmonary Pathology

Updated: 2017-05-24 08:46:09

The SOX-2 protein is part of large family of transcription factors that function in regulating a variety of different processes during embryonic development and maintaining pluripotency of stem cells including germ cells and neural cells.1-4 Dysregulation of SOX-2 can lead to malignancies in many organ systems, specifically lung carcinomas, non-seminomatous germ cell tumors, neuroendocrine cancers and neuroglial tumors.1-4

  1. Sholl LM, et al. SOX2 expression in pulmonary non-small cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol. 2010; 18:55-61.
  2. Gopalan A, et al. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas. Mod Pathol. 2009; 22:1066-74.
  3. Maier S, et al. SOX 2 amplification is a common event in squamous cell carcinomas of different organ sites. Human Pathol. 2011; 42:1078-88.
  4. Phi JH, et al. Sox 2 expression in brain tumors: a reflection of the neuroglial differentiation pathway. Am J Surg Pathol. 2008; 32:103-12.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: lung squamous carcinoma
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute371R-10
0.1 mL concentrate371R-14
0.5 mL concentrate371R-15
1 mL concentrate371R-16
1 mL predilute371R-17
7 mL predilute371R-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute371R-10
0.1 mL concentrate371R-14
0.5 mL concentrate371R-15
1 mL concentrate371R-16
1 mL predilute371R-17
7 mL predilute371R-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute371R-10
0.1 mL concentrate371R-14
0.5 mL concentrate371R-15
1 mL concentrate371R-16
1 mL predilute371R-17
7 mL predilute371R-18

For research use only (RUO) in Japan

25 mL predilute371R-10-RUO
0.1 mL concentrate371R-14-RUO
0.5 mL concentrate371R-15-RUO
1 mL concentrate371R-16-RUO
1 mL predilute371R-17-RUO
7 mL predilute371R-18-RUO

 

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