SOX-2 (SP76) Rabbit Monoclonal Antibody
Specialties: Pulmonary Pathology
The SOX-2 protein is part of large family of transcription factors that function in regulating a variety of different processes during embryonic development and maintaining pluripotency of stem cells including germ cells and neural cells.1-4 Dysregulation of SOX-2 can lead to malignancies in many organ systems, specifically lung carcinomas, non-seminomatous germ cell tumors, neuroendocrine cancers and neuroglial tumors.1-4
- Sholl LM, et al. SOX2 expression in pulmonary non-small cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol. 2010; 18:55-61.
- Gopalan A, et al. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas. Mod Pathol. 2009; 22:1066-74.
- Maier S, et al. SOX 2 amplification is a common event in squamous cell carcinomas of different organ sites. Human Pathol. 2011; 42:1078-88.
- Phi JH, et al. Sox 2 expression in brain tumors: a reflection of the neuroglial differentiation pathway. Am J Surg Pathol. 2008; 32:103-12.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: lung squamous carcinoma
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC37131040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 371R-10 |
| 0.1 mL concentrate | 371R-14 |
| 0.5 mL concentrate | 371R-15 |
| 1 mL concentrate | 371R-16 |
| 1 mL predilute | 371R-17 |
| 7 mL predilute | 371R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 371R-10 |
| 0.1 mL concentrate | 371R-14 |
| 0.5 mL concentrate | 371R-15 |
| 1 mL concentrate | 371R-16 |
| 1 mL predilute | 371R-17 |
| 7 mL predilute | 371R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 371R-10 |
| 0.1 mL concentrate | 371R-14 |
| 0.5 mL concentrate | 371R-15 |
| 1 mL concentrate | 371R-16 |
| 1 mL predilute | 371R-17 |
| 7 mL predilute | 371R-18 |
For research use only (RUO) in Japan
| 25 mL predilute | 371R-10-RUO |
| 0.1 mL concentrate | 371R-14-RUO |
| 0.5 mL concentrate | 371R-15-RUO |
| 1 mL concentrate | 371R-16-RUO |
| 1 mL predilute | 371R-17-RUO |
| 7 mL predilute | 371R-18-RUO |
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