Annexin A1 (MRQ-3) Mouse Monoclonal Antibody

Annexin A1
Hairy cell leukemia cells are strongly stained in cytoplasmic staining pattern.

Annexin A1 (MRQ-3) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 is a useful marker for identifying hairy cell leukemia cells.1 Additionally, aberrant expression of Annexin A1 has been reported in certain types of breast and gastric carcinomas.2-5

  1. Falini B, et al. Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1). Lancet. 2004; 363:1869-70.
  2. Sobral-Leite M, et al. Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis. BMC Med. 2015; 13:156.
  3. Cheng TY, et al. Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. Cancer. 2012; 118:5757-67.
  4. Sato Y, et al. Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis. Exp Ther Med. 2011; 2:239-43.
  5. Wang KL, et al. Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. Clin Cancer Res. 2006; 12:4598-604.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: hairy cell leukemia
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate221M-14
0.5 mL concentrate221M-15
1 mL concentrate221M-16
1 mL predilute221M-17
7 mL predilute221M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate221M-14
0.5 mL concentrate221M-15
1 mL concentrate221M-16
1 mL predilute221M-17
7 mL predilute221M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate221M-14
0.5 mL concentrate221M-15
1 mL concentrate221M-16
1 mL predilute221M-17
7 mL predilute221M-18

For research use only (RUO) in Japan

0.1 mL concentrate221M-14-RUO
0.5 mL concentrate221M-15-RUO
1 mL concentrate221M-16-RUO
1 mL predilute221M-17-RUO
7 mL predilute221M-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information