CD63 (NKI/C3) Mouse Monoclonal Antibody

CD63
CD63 (NKI/C3) on skin.

CD63 (NKI/C3) Mouse Monoclonal Antibody

Specialties: Dermatopathology

Updated: 2017-05-24 08:46:09

CD63 is a 53kDa lysosomal membrane protein in the family of tetraspan moieties, and characterized as an activation dependent platelet surface antigen. Anti-CD63 reactivity is seen in the cytoplasm of many cell types including lymphoid, myeloid, endothelial cells, and the majority of malignant melanomas. Anti-CD63 is a useful immunohistochemical marker for the identification of malignant melanoma.1-4

  1. Azorsa DO, et al. CD63/Pltgp40: a platelet activation antigen identical to the stage-specific, melanoma-associated antigen ME491. Blood. 1991; 78:280-4.
  2. Barrio MM, et al. A new epitope on human melanoma-associated antigen CD63/ME491 expressed by both primary and metastatic melanoma. Hybridoma. 1998; 17:355-64.
  3. Demetrick DJ,et al. ME491 melanoma-associated glycoprotein family: antigenic identity of ME491, NKI/C-3, neuroglandular antigen (NGA), and CD63 proteins. J Natl Cancer Inst. 1992; 84:422-9.
  4. Mete O, et al. Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis. Virchows Arch. 2005; 447:938-46.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: melanoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate263M-14
0.5 mL concentrate263M-15
1 mL concentrate263M-16
1 mL predilute263M-17
7 mL predilute263M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate263M-14
0.5 mL concentrate263M-15
1 mL concentrate263M-16
1 mL predilute263M-17
7 mL predilute263M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate263M-14
0.5 mL concentrate263M-15
1 mL concentrate263M-16
1 mL predilute263M-17
7 mL predilute263M-18

For research use only (RUO) in Japan

0.1 mL concentrate263M-14-RUO
0.5 mL concentrate263M-15-RUO
1 mL concentrate263M-16-RUO
1 mL predilute263M-17-RUO
7 mL predilute263M-18-RUO

 

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